开发评估血管衰老的技术：来自血管衰老网络（VascAgeNet）的路线图。

Developing technologies to assess vascular ageing: a roadmap from VascAgeNet.

作者信息

Zanelli Serena, Agnoletti Davide, Alastruey Jordi, Allen John, Bianchini Elisabetta, Bikia Vasiliki, Boutouyrie Pierre, Bruno Rosa Maria, Climie Rachel, Djeldjli Djammaleddine, Gkaliagkousi Eugenia, Giudici Alessandro, Gopcevic Kristina, Grillo Andrea, Guala Andrea, Hametner Bernhard, Joseph Jayaraj, Karimpour Parmis, Kodithuwakku Vimarsha, Kyriacou Panicos A, Lazaridis Antonios, Lønnebakken Mai Tone, Martina Maria Raffaella, Mayer Christopher Clemens, Nabeel P M, Navickas Petras, Nemcsik János, Orter Stefan, Park Chloe, Pereira Telmo, Pucci Giacomo, Rey Ana Belen Amado, Salvi Paolo, Seabra Ana Carolina Gonçalves, Seeland Ute, van Sloten Thomas, Spronck Bart, Stansby Gerard, Steens Indra, Stieglitz Thomas, Tan Isabella, Veerasingham Dave, Wassertheurer Siegfried, Weber Thomas, Westerhof Berend E, Charlton Peter H

机构信息

Laboratoire Analyse, Géométrie et Applications, Université Sorbonne Paris Nord, Paris, France.

Axelife, Paris, France.

出版信息

Physiol Meas. 2024 Dec 30;45(12):121001. doi: 10.1088/1361-6579/ad548e.

DOI:10.1088/1361-6579/ad548e

PMID:38838703

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11697036/

Abstract

Vascular ageing (vascular ageing) is the deterioration of arterial structure and function which occurs naturally with age, and which can be accelerated with disease. Measurements of vascular ageing are emerging as markers of cardiovascular risk, with potential applications in disease diagnosis and prognosis, and for guiding treatments. However, vascular ageing is not yet routinely assessed in clinical practice. A key step towards this is the development of technologies to assess vascular ageing. In this Roadmap, experts discuss several aspects of this process, including: measurement technologies; the development pipeline; clinical applications; and future research directions. The Roadmap summarises the state of the art, outlines the major challenges to overcome, and identifies potential future research directions to address these challenges.

摘要

血管老化是指动脉结构和功能随着年龄自然发生的衰退，并且疾病会加速这种衰退。血管老化的测量正成为心血管风险的标志物，在疾病诊断、预后评估以及治疗指导方面具有潜在应用价值。然而，在临床实践中，血管老化尚未得到常规评估。实现这一目标的关键一步是开发评估血管老化的技术。在本路线图中，专家们讨论了这一过程的几个方面，包括：测量技术；研发流程；临床应用；以及未来研究方向。该路线图总结了当前的技术水平，概述了需要克服的主要挑战，并确定了应对这些挑战的潜在未来研究方向。