Ferguson Tanner J, Knier Catherine G, Chowdhury Uttio Roy, Monson Kjerseten J, Greenwood Michael, Swan Russell J, Gorham Richard, Berdahl John P, Fautsch Michael P
Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA.
Ophthalmol Ther. 2020 Mar;9(1):127-137. doi: 10.1007/s40123-020-00235-z. Epub 2020 Feb 20.
To investigate the precision and accuracy of IOP measurements using a pneumatonometer and a tonometer tip cover (Tono-Pen tip cover) acting as a membrane between a cadaver eye model and pneumatonometer probe.
A total of 480 paired IOP measurements, with and without a Tono-Pen cover, were collected across 4 pressure levels of 7, 10, 20 and 30 mmHg. IOP measurements were obtained by three different pneumatonometer units paired with three different masked operators (three configurations). Four eyes were sampled for each eye pressure level. The sequence of eye pressure, configuration, and measurements with vs. without the Tono-Pen cover was randomized.
With the Tono-Pen cover in place, there was a negative bias with a mean IOP difference of - 1.18 mmHg for all 480 paired samples compared with the measurements absent the cover. Compared with the test pressure settings (i.e., 7, 10, 20, 30 mmHg), the overall mean bias was + 0.35 mmHg with the Tono-Pen cover present. With the Tono-Pen cover present, the overall repeatability %CV (percent coefficient of variation) was 3.4% and the reproducibility %CV was 3.8% compared with a repeatability %CV of 3.2% and reproducibility %CV of 5.7% without the Tono-Pen cover.
Measurement of IOP via pneumatonometry with a Tono-Pen cover in place, also known as the excursion test method, yields precise, accurate and reproducible results. This developed method of pressure measurement is an acceptable and reliable form of IOP measurement.
研究使用气动眼压计以及作为尸体眼模型与气动眼压计探头之间隔膜的眼压计笔尖套（Tono - Pen笔尖套）进行眼压测量的精密度和准确性。
在7、10、20和30 mmHg这4个压力水平下，共收集了480对有和没有Tono - Pen笔尖套时的眼压测量值。眼压测量由3个不同的气动眼压计单元与3个不同的蒙面操作人员（三种配置）完成。每个眼压水平抽取4只眼进行采样。眼压水平、配置以及有无Tono - Pen笔尖套时的测量顺序均为随机安排。
使用Tono - Pen笔尖套时，与不使用笔尖套的测量值相比，480对样本的平均眼压差异为 -1.18 mmHg，存在负偏差。与测试压力设置（即7、10、20、30 mmHg）相比，使用Tono - Pen笔尖套时的总体平均偏差为 +0.35 mmHg。使用Tono - Pen笔尖套时，总体重复性变异系数百分比（%CV）为3.4%，再现性变异系数百分比为3.8%；而不使用Tono - Pen笔尖套时，重复性变异系数百分比为3.2%，再现性变异系数百分比为5.7%。
通过使用Tono - Pen笔尖套的气动眼压测量法（也称为偏移测试法）测量眼压，可得出精确、准确且可重复的结果。这种开发的压力测量方法是一种可接受且可靠的眼压测量形式。
