Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik für Radiologie, Augustenburger Platz 1, 13353, Berlin, Germany.
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik für Nuklearmedizin, Augustenburger Platz 1, 13353, Berlin, Germany.
Sci Rep. 2020 Feb 20;10(1):3121. doi: 10.1038/s41598-020-59942-z.
Purpose of this study was to evaluate the diagnostic performance of T1 relaxation time (T1) for differentiating prostate cancer (PCa) from benign tissue as well as high- from low-grade PCa. Twenty-three patients with suspicion for PCa were included in this prospective study. 3 T MRI including a Modified Look-Locker inversion recovery sequence was acquired. Subsequent targeted and systematic prostate biopsy served as a reference standard. T1 and apparent diffusion coefficient (ADC) value in PCa and reference regions without malignancy as well as high- and low-grade PCa were compared using the Mann-Whitney U test. The performance of T1, ADC value, and a combination of both to differentiate PCa and reference regions was assessed by receiver operating characteristic (ROC) analysis. T1 and ADC value were lower in PCa compared to reference regions in the peripheral and transition zone (p < 0.001). ROC analysis revealed high AUCs for T1 (0.92; 95%-CI, 0.87-0.98) and ADC value (0.97; 95%-CI, 0.94 to 1.0) when differentiating PCa and reference regions. A combination of T1 and ADC value yielded an even higher AUC. The difference was statistically significant comparing it to the AUC for ADC value alone (p = 0.02). No significant differences were found between high- and low-grade PCa for T1 (p = 0.31) and ADC value (p = 0.8). T1 relaxation time differs significantly between PCa and benign prostate tissue with lower T1 in PCa. It could represent an imaging biomarker for PCa.
本研究旨在评估 T1 弛豫时间（T1）在区分前列腺癌（PCa）与良性组织以及区分高级别和低级别 PCa 中的诊断性能。这项前瞻性研究纳入了 23 名疑似患有 PCa 的患者。采用 3T MRI 包括改良的 Look-Locker 反转恢复序列进行采集。随后进行靶向和系统前列腺活检作为参考标准。使用 Mann-Whitney U 检验比较 PCa 和无恶性肿瘤的参考区域以及高级别和低级别 PCa 中的 T1 和表观扩散系数（ADC）值。通过接受者操作特征（ROC）分析评估 T1、ADC 值以及两者结合来区分 PCa 和参考区域的性能。与外周带和移行带的参考区域相比，PCa 中的 T1 和 ADC 值较低（p<0.001）。ROC 分析显示，T1（0.92；95%CI，0.87-0.98）和 ADC 值（0.97；95%CI，0.94 至 1.0）在区分 PCa 和参考区域时具有较高的 AUC。T1 和 ADC 值的组合产生了更高的 AUC。与单独使用 ADC 值的 AUC 相比，差异具有统计学意义（p=0.02）。T1（p=0.31）和 ADC 值（p=0.8）在高级别和低级别 PCa 之间无显著差异。T1 弛豫时间在 PCa 与良性前列腺组织之间存在显著差异，PCa 中的 T1 较低。它可能是 PCa 的一种成像生物标志物。
