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利用国家髋部骨折登记处评估在出院后接受抗骨质疏松治疗的患者的特征。

Usefulness of a national hip fracture registry to evaluate the profile of patients in whom antiosteoporotic treatment is prescribed following hospital discharge.

机构信息

Hospital Universitario La Paz, Madrid, Spain.

Instituto de Investigación del Hospital La Paz (IdiPAZ), Madrid, Spain.

出版信息

Osteoporos Int. 2020 Jul;31(7):1369-1375. doi: 10.1007/s00198-020-05341-z. Epub 2020 Feb 20.

Abstract

UNLABELLED

This study was carried out to describe the profile of prescription of antiosteoporotic treatment at discharge after a hip fracture in the Spanish National Hip Fracture Registry. Prescription rates among hospitals ranged from 0 to 94% of patients discharged. The prescription rate was higher among patients with better cognitive and functional baseline status.

PURPOSE

National hip fracture registries are useful for assessing current care processes. The goals of this study were as follows: first, to know the rate of antiosteoporotic prescription at discharge among hip fracture patients in hospitals participating in the Spanish National Hip Fracture Registry (RNFC); second, to compare the differences between treated and non-treated patients; third, to analyze patients' characteristics associated with antiosteoporotic prescription at discharge; and fourth, to evaluate whether there were differences in the profile of patients discharged from hospitals with high and low prescription rates.

METHOD

Patients discharged after a fragility hip fracture in 2017 and participating in the RNFC were included. Demographic variables, cognitive and functional status, prefracture osteoporosis treatment, fracture type, anesthetic risk, hospital volume, and antiosteoporotic prescription at discharge were analyzed. Given that patients were clustered within hospitals, intraclass correlation was calculated and generalized estimating equations were fitted.

RESULTS

A total of 6701 patients from 54 hospitals were included. Antiosteoporotic prescription at discharge was prescribed to 36.5% (CI95% 35.8-37.2%), with a wide inter-hospital variability (range 0-94%). The intraclass correlation due of clustering of patients within hospitals was 47.9%. Antiosteoporotic prescription was more likely in patients who were younger, lived at home, previously treated for osteoporosis, had better baseline functional and cognitive status, lower anesthetic risk, and were discharged from high-volume hospitals, all with p < 0.001. The general profile of patients discharged from hospitals with high and low rate of prescription was similar.

CONCLUSIONS

There is a wide variability between hospitals regarding antiosteoporotic prescription after hip fracture. This is more likely to be initiated in patients with better clinical, functional, and mental status and in those discharged from hospitals with larger volumes of patients. These results offer insights regarding the selection of patients receiving secondary prevention and raises questions on who and how many should be treated.

摘要

目的

国家髋部骨折登记处对于评估当前的护理流程非常有用。本研究的目的如下:首先,了解参与西班牙国家髋部骨折登记处(RNFC)的医院中髋部骨折患者出院时的抗骨质疏松治疗处方率;其次,比较治疗和未治疗患者之间的差异;第三,分析与出院时抗骨质疏松治疗处方相关的患者特征;最后,评估处方率较高和较低的医院出院患者的特征是否存在差异。

方法

纳入 2017 年因脆性髋部骨折出院且参与 RNFC 的患者。分析人口统计学变量、认知和功能状态、骨折前骨质疏松治疗、骨折类型、麻醉风险、医院容量和出院时的抗骨质疏松治疗处方。由于患者在医院内呈聚集性,计算了组内相关系数并拟合了广义估计方程。

结果

共纳入 54 家医院的 6701 例患者。出院时开具抗骨质疏松药物的比例为 36.5%(95%CI 35.8-37.2%),医院间差异较大(范围 0-94%)。由于患者在医院内聚集导致的组内相关系数为 47.9%。在年龄较小、居住在家庭、骨折前接受过骨质疏松治疗、基线功能和认知状态较好、麻醉风险较低、从高容量医院出院的患者中,更有可能开具抗骨质疏松药物,所有这些差异均有统计学意义(p<0.001)。处方率较高和较低的医院出院患者的总体特征相似。

结论

各医院出院时开具抗骨质疏松药物的情况存在较大差异。这种情况更可能发生在临床、功能和精神状态较好的患者中,也更可能发生在患者容量较大的医院中。这些结果提供了有关接受二级预防患者选择的见解,并提出了应该治疗哪些患者以及治疗多少患者的问题。

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