School of Pharmacy, Nantong University, Nantong, China.
Histol Histopathol. 2020 Aug;35(8):779-787. doi: 10.14670/HH-18-211. Epub 2020 Feb 21.
Perivascular adipose tissue (PVAT) had long been considered to serve only structural, vessel-supporting purposes, but today PVAT is recognized to be an endocrine organ with important physiological and pathological effects. The expansion of PVAT in vascular homeostasis and vascular disease has attracted much interest. PVAT has been shown to release a wide spectrum of molecules, such as PVAT-derived relaxing factors (PVATRFs) and PVAT-derived contracting factors (PVATCFs). PVAT dysfunction may lead to obesity, atherosclerosis, and other cardiovascular diseases. This review describes recent advances in our understanding of PVAT's important effects on the cardiovascular system.
血管周围脂肪组织（PVAT）长期以来一直被认为仅具有结构上的、支持血管的作用，但如今已认识到它是一个具有重要生理和病理作用的内分泌器官。PVAT 在血管稳态和血管疾病中的扩张引起了广泛关注。已经表明，PVAT 释放出广泛的分子，如 PVAT 衍生的舒张因子（PVATRFs）和 PVAT 衍生的收缩因子（PVATCFs）。PVAT 功能障碍可能导致肥胖、动脉粥样硬化和其他心血管疾病。本综述描述了我们对 PVAT 对心血管系统的重要影响的理解的最新进展。
