抑制剂的效力取决于其芳环在疏水性特异性口袋内的可及性：这是未来醛糖还原酶抑制剂设计的新途径。

1

J Biomol Struct Dyn. 2021 Mar;39(4):1512-1518. doi: 10.1080/07391102.2020.1733090. Epub 2020 Mar 3.

2

J Biomol Struct Dyn. 2020 Mar;38(4):1234-1241. doi: 10.1080/07391102.2019.1592023. Epub 2019 Apr 7.

3

Proteins. 1997 Oct;29(2):186-92. doi: 10.1002/(sici)1097-0134(199710)29:2<186::aid-prot6>3.0.co;2-b.

4

Biochemistry. 1995 Sep 5;34(35):11264-75. doi: 10.1021/bi00035a036.

5

Biomolecules. 2021 Dec 6;11(12):1837. doi: 10.3390/biom11121837.

6

Bioorg Med Chem. 1995 Oct;3(10):1313-24. doi: 10.1016/0968-0896(95)00118-z.

7

J Mol Biol. 2007 May 4;368(3):618-38. doi: 10.1016/j.jmb.2006.12.004. Epub 2006 Dec 15.

8

Structure. 1997 May 15;5(5):601-12. doi: 10.1016/s0969-2126(97)00216-5.

9

Mol Vis. 1998 Sep 29;4:19.

10

J Med Chem. 1992 Mar 20;35(6):1117-20. doi: 10.1021/jm00084a017.

Potency of inhibitors depends upon the accessibility of their aromatic rings within the hydrophobic specificity pocket: a novel avenue for future aldose reductase inhibitor design.