帕金森病中轻度认知障碍和痴呆的影像学表现
Imaging Mild Cognitive Impairment and Dementia in Parkinson's Disease.
作者信息
Sasikumar Sanskriti, Strafella Antonio P
机构信息
Division of Neurology, University of Toronto, Toronto, ON, Canada.
Morton and Gloria Shulman Movement Disorder Unit & E. J. Safra Parkinson Disease Program, Neurology Division, Department of Medicine, Toronto Western Hospital, UHN, University of Toronto, Toronto, ON, Canada.
出版信息
Front Neurol. 2020 Jan 31;11:47. doi: 10.3389/fneur.2020.00047. eCollection 2020.
Abstract
Cognitive dysfunction is a significant non-motor feature of Parkinson's disease, with the risk of dementia increasing with prolonged disease duration. Multiple cognitive domains are affected, and the pathophysiology cannot be explained by dopaminergic loss alone. Sophisticated neuroimaging techniques can detect the nature and extent of extra-nigral involvement by targeting neurotransmitters, abnormal protein aggregates and tissue metabolism. This review identifies the functional and anatomical imaging characteristics that predict cognitive impairment in PD, the limitations that challenge this process, and the avenues of potential research.
摘要
认知功能障碍是帕金森病的一个重要非运动特征，痴呆风险随疾病持续时间延长而增加。多个认知领域受到影响，其病理生理学不能仅用多巴胺能缺失来解释。先进的神经成像技术可以通过针对神经递质、异常蛋白质聚集体和组织代谢来检测黑质外受累的性质和程度。本综述确定了预测帕金森病认知障碍的功能和解剖成像特征、这一过程面临的挑战以及潜在的研究途径。
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