Tang Guo-Hui, Chen Xue, Ding Jian-Cheng, Du Jun, Lin Xiao-Ting, Xia Lu, Lian Jia-Bian, Ye Feng, He Xiu-Sheng, Liu Wen
Hunan Provincial Key Laboratory of Cancer Cellular and Molecular Pathology, University of South China, Hengyang, China.
Cancer Research Institute of Hengyang Medical College, University of South China, Hengyang, China.
Front Genet. 2020 Jan 31;10:1409. doi: 10.3389/fgene.2019.01409. eCollection 2019.
Colorectal cancer (CRC) is the second most common cause of cancer-related death worldwide, and is well known for its strong invasiveness, rapid recurrence, and poor prognosis. Long non-coding RNAs (lncRNAs) have been shown to be involved in the development of various types of cancers, including colorectal cancer. Here, through transcriptomic analysis and functional screening, we reported that lncRNA LUCRC (LncRNA Upregulated in Colorectal Cancer) is highly expressed in colorectal tumor samples and is required for colorectal cancer cell proliferation, migration, and invasion in cultured cells and tumorigenesis in xenografts. LUCRC was found to regulate target gene expression of unfolded protein response (UPR) in endoplasmic reticulum (ER), such as BIP. The clinical significance of LUCRC is underscored by the specific presence of LUCRC in blood plasma of patients with colorectal cancers. These findings revealed a critical regulator of colorectal cancer development, which might serve as a therapeutic target in colorectal cancer.
结直肠癌（CRC）是全球癌症相关死亡的第二大常见原因，以其强大的侵袭性、快速复发和不良预后而闻名。长链非编码RNA（lncRNAs）已被证明参与包括结直肠癌在内的各种类型癌症的发展。在这里，通过转录组分析和功能筛选，我们报告lncRNA LUCRC（结直肠癌中上调的LncRNA）在结直肠肿瘤样本中高度表达，并且是培养细胞中结直肠癌细胞增殖、迁移和侵袭以及异种移植中肿瘤发生所必需的。发现LUCRC调节内质网（ER）中未折叠蛋白反应（UPR）的靶基因表达，如BIP。结直肠癌患者血浆中LUCRC的特异性存在强调了LUCRC的临床意义。这些发现揭示了结直肠癌发展的关键调节因子，其可能作为结直肠癌的治疗靶点。
