Meliti Abdelrazak, Hafiz Bayan, Al-Maghrabi Haneen, Gari Abdulrahim
Department of Anatomic Pathology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
Case Rep Pathol. 2020 Feb 3;2020:7568671. doi: 10.1155/2020/7568671. eCollection 2020.
Germ cell neoplasms represent around 20% of all ovarian tumors. They most frequently affect children and young adults. Mature cystic teratoma is a common benign ovarian neoplasm comprising about 95% and is made up of all three germ cell embryonic layers. By definition, mature cystic teratoma may be derived from any of the three germ cell lines. On the other hand, immature teratomas contain primitive neuroepithelial elements. However, it is quite uncommon in the English literature to have a neuroepithelial glial neoplasm arising in a mature cystic teratoma of an adolescent. Interestingly enough, all published cases described a single type of glial neoplasm arising in mature ovarian teratoma. Herein, the authors discuss a unique case of concomitant occurrence of two different glial neoplasms, namely pilocytic astrocytoma and subependymoma arising in an ovarian mature cystic teratoma. To the best of our knowledge, this is the first reported case with such a distinctive histopathologic finding.
生殖细胞肿瘤约占所有卵巢肿瘤的20%。它们最常影响儿童和年轻成年人。成熟囊性畸胎瘤是一种常见的卵巢良性肿瘤，约占95%，由所有三个生殖细胞胚胎层组成。根据定义，成熟囊性畸胎瘤可能源自三个生殖细胞系中的任何一个。另一方面，未成熟畸胎瘤含有原始神经上皮成分。然而，在英文文献中，青少年成熟囊性畸胎瘤中出现神经上皮胶质肿瘤的情况相当罕见。有趣的是，所有已发表的病例都描述了成熟卵巢畸胎瘤中出现的单一类型的胶质肿瘤。在此，作者讨论了一个独特的病例，即在卵巢成熟囊性畸胎瘤中同时出现两种不同的胶质肿瘤，即毛细胞型星形细胞瘤和室管膜下瘤。据我们所知，这是首例有如此独特组织病理学发现的报道病例。
