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保留肺动脉瓣技术对法洛四联症修复术后早期及中期结果的影响。

The impact of pulmonary valve-sparing techniques on postoperative early and midterm results in tetralogy of Fallot repair.

作者信息

Aydın Selim, Suzan Dilek, Temur Bahar, Kırat Barış, İyigün Müzeyyen, Demir İbrahim Halil, Ödemiş Ender, Erek Ersin

机构信息

Department of Cardiovascular Surgery, Medicine Faculty of Acıbadem Mehmet Ali Aydınlar University, Atakent Hospital, İstanbul, Turkey.

Department of Anesthesiology and Reanimation, Medicine Faculty of Acıbadem Mehmet Ali Aydınlar University, Atakent Hospital, İstanbul, Turkey.

出版信息

Turk Gogus Kalp Damar Cerrahisi Derg. 2018 Jul 3;26(3):370-374. doi: 10.5606/tgkdc.dergisi.2018.15499. eCollection 2018 Jul.

Abstract

BACKGROUND

In this study, we analyzed the impact of pulmonary valve-sparing techniques on early and midterm postoperative results of tetralogy of Fallot repair.

METHODS

A total of 64 patients diagnosed with tetralogy of Fallot, who underwent total correction operation by the same surgeon between November 2010 and September 2015 were included in this retrospective study. Mean age of the patients was 20.0±14.2 months (5.5-96 months). Forty patients (62.5%) were male. Thirty two of the patients (50%) were under one year of age. Pulmonary valve-sparing techniques were performed in 29 patients (Group 2), while transannular patch was applied in the remaining 35 patients (Group 1). Pericardial monocusp valve was constructed in 15 patients in Group 1. In Group 2, pulmonary valve-sparing techniques were transatrial repair in nine patients; transatrial-transpulmonary in eight, infundibular patch in eight, and infundibular-pulmonary patch in four patients.

RESULTS

There was no early postoperative mortality in Group 2. Five patients (14.2%) in Group 1 died in the early postoperative period (p=0.058). Pulmonary monocusp insertion was performed in 2 (13.3%) of these patients (p=1). The causes of mortality were sudden cardiac arrest (n=2), multiorgan failure (n=1), low cardiac output (n=1), and neurological complications (n=1). Five patients in Group 1 required extracorporeal membrane oxygenation support (ECMO). Three of them were separated from ECMO and two of the patients that were separated were discharged uneventfully. Total postoperative morbidity rate was significantly higher in Group 1 (51.4% vs. 6.8%) (p=0.0001). Morbidity rate was significantly lower in patients with pulmonary monocusp insertion than patients in the same group without a monocusp (p=0.0176). Forty nine (83%) of the patients were followed up for a median of 6.5 (1-24) months. While free pulmonary regurgitation was detected in all non-monocusp patients in Group 1, pulmonary regurgitation was absent or mild in Group 2. Twelve (80%) of the patients in Group 1 who had monocusp insertion were followed up. Only two of these patients had free pulmonary regurgitation (16.6%). The rest of them had mild (n=6) or mildmoderate pulmonary regurgitation (n=4).

CONCLUSION

Mortality and morbidity rates are lower when pulmonary valvesparing techniques are used in repair of tetralogy of Fallot. Monocusp pulmonary valve insertion may improve results in patients who require transannular patch repair. It is suggested that every effort should be made to achieve a competently working pulmonary valve during repair.

摘要

背景

在本研究中,我们分析了保留肺动脉瓣技术对法洛四联症修复术后早期和中期结果的影响。

方法

本回顾性研究纳入了2010年11月至2015年9月间由同一位外科医生进行完全矫正手术的64例法洛四联症患者。患者的平均年龄为20.0±14.2个月(5.5 - 96个月)。40例患者(62.5%)为男性。32例患者(50%)年龄在1岁以下。29例患者(第2组)采用了保留肺动脉瓣技术,其余35例患者(第1组)应用了跨环补片。第1组中有15例患者构建了心包单叶瓣。在第2组中,9例患者采用经心房修复的保留肺动脉瓣技术;8例采用经心房 - 经肺动脉技术,8例采用漏斗部补片,4例采用漏斗部 - 肺动脉补片。

结果

第2组术后早期无死亡病例。第1组有5例患者(14.2%)在术后早期死亡(p = 0.058)。其中2例患者(13.3%)进行了肺动脉单叶瓣植入(p = 1)。死亡原因包括心搏骤停(n = 2)、多器官功能衰竭(n = 1)、低心排血量(n = 1)和神经系统并发症(n = 1)。第1组有5例患者需要体外膜肺氧合支持(ECMO)。其中3例脱离了ECMO,脱离ECMO的2例患者顺利出院。第1组的术后总发病率显著高于第2组(51.4%对6.8%)(p = 0.0001)。肺动脉单叶瓣植入患者的发病率显著低于同组未植入单叶瓣的患者(p = 0.0176)。49例(83%)患者接受了随访,中位随访时间为6.5(1 - 24)个月。第1组所有非单叶瓣患者均检测到明显的肺动脉反流,而第2组肺动脉反流不存在或为轻度。第1组中12例(80%)进行了单叶瓣植入的患者接受了随访。这些患者中只有2例有明显的肺动脉反流(16.6%)。其余患者为轻度(n = 6)或轻度 - 中度肺动脉反流(n = 4)。

结论

在法洛四联症修复术中使用保留肺动脉瓣技术时,死亡率和发病率较低。肺动脉单叶瓣植入可能改善需要跨环补片修复患者的手术结果。建议在修复过程中应尽一切努力使肺动脉瓣功能良好。

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