Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
Chem Commun (Camb). 2020 Mar 17;56(22):3329-3332. doi: 10.1039/c9cc09433d.
Taxodisones A and B, C30-terpenes with an unprecedented tetracyclo[12.4.0.0.2,709,14]octodecane core, were isolated from the seeds of Taxodium distichum. Their structures, including their configurations, were unambiguously determined. Their biomimetic synthesis suggests that they stem from diterpenes and monoterpenes, and not from squalene or oxidosqualene. In addition, their bioactivities were also evaluated.
紫杉烷 A 和 B，具有前所未有的四环[12.4.0.0.2,7,09,14]辛烷核心的 C30-萜烯，从落羽杉的种子中分离得到。它们的结构，包括它们的构型，都被明确地确定了。它们的仿生合成表明它们源自二萜和单萜，而不是鲨烯或氧化鲨烯。此外，还评估了它们的生物活性。
