Starks Courtney M, Norman Vanessa L, Williams Russell B, Goering Matt G, Rice Stephanie M, O'Neil-Johnson Mark, Eldridge Gary R
Nat Prod Commun. 2014 Aug;9(8):1129-30.
One new and seven known diterpenes were identified from an antibacterial chromatographic fraction of Taxodium ascendens. Of these, demethylcryptojaponol (2), 6-hydroxysalvinolone (3), hydroxyferruginol (4), and hinokiol (5) demonstrated potent activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). These compounds represent a class of synthetically accessible compounds that could be further developed for treatment of drug-resistant bacterial infections.
从池杉的抗菌色谱馏分中鉴定出一种新的二萜和七种已知的二萜。其中，去甲基隐日本醇（2）、6-羟基萨尔维诺酮（3）、羟基铁锈醇（4）和日扁柏醇（5）对耐甲氧西林金黄色葡萄球菌（MRSA）临床分离株表现出强效活性。这些化合物代表了一类可通过合成获得的化合物，可进一步开发用于治疗耐药细菌感染。
