Division of Paediatric Haematology/Oncology, Department of Paediatrics, McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada.
Section of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Pediatr Blood Cancer. 2020 Jun;67 Suppl 3:e28207. doi: 10.1002/pbc.28207. Epub 2020 Feb 21.
The overall survival for children with cancer in high income countries is excellent. However, there are many disparities that may negatively affect survival, which are particularly problematic in low income countries, such as nutritional status at diagnosis and throughout therapy. Nutritional status as well as concomitant foods, supplements, and medications may play a role in overall exposure and response to chemotherapy. Emerging science around the microbiome may also play a role and should be further explored as a contributor to disease progression and therapeutic response. This article highlights some of these issues and proposes additional areas of research relevant to nutritional status and pharmacology that are needed in pediatric oncology.
高收入国家儿童癌症的总体生存率非常高。然而，存在许多可能对生存率产生负面影响的差异，这些差异在低收入国家尤为突出，例如诊断时和治疗期间的营养状况。营养状况以及同时摄入的食物、补充剂和药物可能会影响到整体的化疗暴露和反应。有关微生物组的新兴科学也可能发挥作用，应该进一步探讨其作为疾病进展和治疗反应的一个促成因素。本文重点介绍了其中的一些问题，并提出了儿科肿瘤学中需要研究的与营养状况和药理学相关的其他领域。
