College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Int J Neurosci. 2021 Jan;131(1):95-101. doi: 10.1080/00207454.2020.1733557. Epub 2020 Mar 11.
Recent studies have found that selenium (Se) levels were associated with the risk of Parkinson's disease (PD), but the results were contradictory. Therefore, this meta-analysis was conducted to investigate the correlation between Se levels and PD. PubMed, Embase and Web of Science were searched published up to 28 October 2019. The differences between groups were analyzed by forest plots and results were pooled and assessed using a random-effect model. Standardized mean difference (SMD) and 95% confidence interval (CI) were used to assess the association between Se levels and the risk of PD. Subgroup analysis, meta-regression, and sensitivity analysis were also conducted. Publication bias was estimated using Begg's regression asymmetry test. Finally, 12 articles involving 601 PD patients and 749 controls were included in this meta-analysis. The meta-analysis revealed a significantly higher cerebrospinal fluid (CSF) Se level in PD patients than those in controls (SMD = 1.22; 95%CI [0.05, 2.39]; = 0.000). No publication bias was found. The meta-analysis indicated that CSF Se levels in PD patients were significantly higher than those in controls.
最近的研究发现，硒（Se）水平与帕金森病（PD）的风险有关，但结果相互矛盾。因此，进行了这项荟萃分析，以调查 Se 水平与 PD 之间的相关性。检索了截至 2019 年 10 月 28 日发表的 PubMed、Embase 和 Web of Science。通过森林图分析组间差异，并使用随机效应模型对结果进行汇总和评估。使用标准化均数差（SMD）和 95%置信区间（CI）来评估 Se 水平与 PD 风险之间的关联。还进行了亚组分析、荟萃回归和敏感性分析。使用 Begg 的回归不对称检验估计发表偏倚。最终，这项荟萃分析纳入了 12 篇文章，涉及 601 名 PD 患者和 749 名对照。荟萃分析显示，PD 患者的脑脊液（CSF）Se 水平明显高于对照组（SMD=1.22；95%CI[0.05，2.39]；=0.000）。未发现发表偏倚。荟萃分析表明，PD 患者的 CSF Se 水平明显高于对照组。
