School of Medicine, Shanghai Jiao Tong University, No.227 Chongqing Rd (S), Shanghai, China.
Department of neurology, Xinhua Hospital, Shanghai Jiao tong University School of Medicine, No.1665 Kongjiang Rd, Shanghai, China.
BMC Geriatr. 2024 May 10;24(1):415. doi: 10.1186/s12877-024-05000-6.
Parkinson's disease (PD) is a slowly progressive neurodegenerating disease that may eventually lead to disabling condition and pose a threat to the health of aging populations. This study aimed to explore the association of two potential risk factors, selenium and cadmium, with the prognosis of Parkinson's disease as well as their interaction effect.
Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2005-2006 to 2015-2016 and National Death Index (NDI). Participants were classified as Parkinson's patients by self-reported anti-Parkinson medications usage. Cox regression models and restricted cubic spline models were applied to evaluate the association between PD mortality and selenium intake level as well as blood cadmium level. Subgroup analysis was also conducted to explore the interaction between them.
A total of 184 individuals were included. In full adjusted cox regression model (adjusted for age, gender, race, hypertension, pesticide exposure, smoking status and caffeine intake), compared with participants with low selenium intake, those with normal selenium intake level were significantly associated with less risk of death (95%CI: 0.18-0.76, P = 0.005) while no significant association was found between low selenium intake group and high selenium group (95%CI: 0.16-1.20, P = 0.112). Restricted cubic spline model indicated a nonlinear relationship between selenium intake and PD mortality (P for nonlinearity = 0.050). The association between PD mortality and blood cadmium level was not significant (95%CI: 0.19-5.57, P = 0.112). However, the interaction term of selenium intake and blood cadmium showed significance in the cox model (P for interaction = 0.048). Subgroup analysis showed that the significant protective effect of selenium intake existed in populations with high blood cadmium but not in populations with low blood cadmium.
Moderate increase of selenium intake had a protective effect on PD mortality especially in high blood cadmium populations.
帕金森病（PD）是一种进行性神经退行性疾病，最终可能导致致残，并威胁到老年人口的健康。本研究旨在探讨两种潜在的危险因素——硒和镉与帕金森病预后的关系及其相互作用。
数据来自 2005-2006 年至 2015-2016 年的国家健康与营养调查（NHANES）和国家死亡指数（NDI）。参与者通过自我报告的抗帕金森药物使用情况被分类为帕金森病患者。Cox 回归模型和限制性立方样条模型被用于评估 PD 死亡率与硒摄入量以及血镉水平之间的关系。还进行了亚组分析，以探讨它们之间的相互作用。
共纳入 184 人。在全调整 Cox 回归模型（调整年龄、性别、种族、高血压、农药暴露、吸烟状况和咖啡因摄入）中，与低硒摄入组相比，正常硒摄入组的死亡风险显著降低（95%CI：0.18-0.76，P=0.005），而低硒摄入组与高硒摄入组之间无显著相关性（95%CI：0.16-1.20，P=0.112）。限制性立方样条模型表明，硒摄入量与 PD 死亡率之间存在非线性关系（非线性检验 P=0.050）。血镉水平与 PD 死亡率之间无显著相关性（95%CI：0.19-5.57，P=0.112）。然而，硒摄入量与血镉的交互项在 Cox 模型中具有统计学意义（交互检验 P=0.048）。亚组分析显示，在高血镉人群中，硒摄入的显著保护作用存在，但在低血镉人群中不存在。
适度增加硒摄入对 PD 死亡率有保护作用，特别是在高血镉人群中。
