Department of Clinical Laboratory Medicine, Southwest Hospital, Army Medical University, Chongqing, China.
Department of Nuclear Medicine, Southwest Hospital, Army Medical University, Chongqing, China.
Medicine (Baltimore). 2024 Apr 26;103(17):e37919. doi: 10.1097/MD.0000000000037919.
Parkinson disease (PD) is a common neurodegenerative disorder, but its pathogenesis is still not entirely understood. While some trace elements, such as selenium, iron, and copper, are considered pivotal in PD onset due to their role in oxidative stress, the association between selenium concentrations and PD susceptibility remains ambiguous.
A systematic review and meta-analysis was conducted in adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and framed by the Patient, Intervention, Comparison, Outcome paradigm. Data were sourced from 4 prominent electronic databases: PubMed, Embase, Web of Science, and Cochrane Library. Eligible studies must have had a PD case group and a control group, both of which presented data on selenium concentrations. The quality of the studies was assessed using the Newcastle-Ottawa Scale.
Of 1541 initially identified articles, 12 studies comprising a total of 597 PD cases and 733 controls were selected for the meta-analysis. Pronounced heterogeneity was observed among these studies. When assessing blood selenium levels, no significant difference was found between patients with PD and the controls. However, when examining the cerebrospinal fluid, selenium levels in PD patients were significantly elevated compared to controls (standard mean difference = 1.21, 95% CI 0.04-2.39, P < .05). Subgroup analyses, sensitivity analyses, and evaluation of publication bias were performed to ensure data robustness.
Elevated selenium levels in cerebrospinal fluid may be associated with a higher risk of Parkinson. Further prospective research is required to solidify this potential link and to offer avenues for novel therapeutic interventions or preventive measures.
帕金森病（PD）是一种常见的神经退行性疾病，但发病机制仍不完全清楚。虽然一些微量元素，如硒、铁和铜，由于其在氧化应激中的作用被认为在 PD 发病中起关键作用，但硒浓度与 PD 易感性之间的关联仍不清楚。
本研究遵循系统评价和荟萃分析的 Preferred Reporting Items 指南，并采用患者、干预、比较、结局（Patient, Intervention, Comparison, Outcome，PICO）范式进行。数据来源于 4 个主要的电子数据库：PubMed、Embase、Web of Science 和 Cochrane Library。纳入的研究必须有 PD 病例组和对照组，且两组均提供了硒浓度的数据。研究质量使用 Newcastle-Ottawa 量表进行评估。
在最初确定的 1541 篇文章中，有 12 项研究共纳入 597 例 PD 病例和 733 例对照，进行了荟萃分析。这些研究之间存在明显的异质性。在评估血液硒水平时，PD 患者与对照组之间没有显著差异。然而，当检查脑脊液时，PD 患者的硒水平明显高于对照组（标准均数差=1.21，95%置信区间 0.04-2.39，P<.05）。进行了亚组分析、敏感性分析和发表偏倚评估，以确保数据稳健性。
脑脊液中硒水平升高可能与帕金森病风险增加有关。需要进一步的前瞻性研究来确定这种潜在联系，并为新的治疗干预或预防措施提供途径。
