Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand, India.
Cellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Jodhpur 342011, Rajasthan, India.
Int J Biol Macromol. 2020 May 15;151:467-482. doi: 10.1016/j.ijbiomac.2020.02.179. Epub 2020 Feb 19.
Protein nanocomposites have attracted considerable research interest in recent times owing to the combined advantageous properties of nanotechnology and proteins. Lysozyme holds enormous potential in various biomedical applications as it possesses antibacterial properties, anti-inflammatory, anti-cancer, and analgesic properties. Considering its multifunctional aspects, structural stability and ease of production and modification, special focus has been attributed to this protein. Nanocomposites have either been fabricated completely from lysozyme or have been conjugated to lysozyme considering its versatile biotechnological applications. The current review describes the recent advances of protein nanocomposites using lysozyme as a prime example. Along with the principles, techniques, and applications involved in protein based nanocomposites, this review also provides a comprehensive account of interactions between lysozyme and different nanoparticles. Numerous studies that have integrated the utilization of lysozyme and nanotechnology for a variety of applications have also been discussed at length.
近年来，由于纳米技术和蛋白质的综合优势，蛋白质纳米复合材料引起了相当大的研究兴趣。溶菌酶在各种生物医学应用中具有巨大的潜力，因为它具有抗菌、抗炎、抗癌和止痛的特性。鉴于其多功能性、结构稳定性以及易于生产和修饰，人们特别关注这种蛋白质。纳米复合材料要么完全由溶菌酶制成，要么考虑到其广泛的生物技术应用与溶菌酶结合。本综述以溶菌酶为例，描述了蛋白质纳米复合材料的最新进展。除了涉及蛋白质基纳米复合材料的原理、技术和应用之外，本综述还全面介绍了溶菌酶与不同纳米颗粒之间的相互作用。还详细讨论了许多将溶菌酶和纳米技术结合用于各种应用的研究。
