Key Laboratory of Science & Technology of Eco-Textile, Donghua University, Ministry of Education, Shanghai 201620, China.
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, North Ren Min Road No. 2999, Shanghai 201620, China.
Curr Med Chem. 2019;26(8):1377-1388. doi: 10.2174/0929867324666170920163156.
An emerging focus in nanomedicine is the exploration of multifunctional nanocomposite materials that integrate stimuli-responsive, therapeutic, and/or diagnostic functions. In this effort, cysteine-rich proteins have drawn considerable attention as a versatile platform due to their good biodegradability, biocompatibility, and ease of chemical modification. This review surveys cysteine-rich protein-based biomedical materials, including protein-metal nanohybrids, gold nanoparticle-protein agglomerates, protein-based nanoparticles, and hydrogels, with an emphasis on their preparation methods, especially those based on the cysteine residue-related reactions. Their applications in tumor-targeted drug delivery and diagnostics are highlighted.
纳米医学的一个新兴焦点是探索多功能纳米复合材料，这些材料集成了刺激响应、治疗和/或诊断功能。在这方面，富含半胱氨酸的蛋白质因其良好的生物降解性、生物相容性和易于化学修饰而作为多功能平台引起了相当大的关注。本综述调查了富含半胱氨酸的蛋白质基生物医学材料，包括蛋白-金属纳米杂化物、金纳米粒子-蛋白聚集体、基于蛋白的纳米粒子和水凝胶，重点介绍了它们的制备方法，特别是基于半胱氨酸残基相关反应的方法。还强调了它们在肿瘤靶向药物输送和诊断中的应用。
