Martín Mateo M C, Martín G
Department of Biochemistry and Molecular Biology, Facultad de Ciencias, Universidad de Valladolid, España.
Clin Physiol Biochem. 1988;6(6):321-6.
We have found changes in the metabolism of trace elements undergoing cancerogenic processes. Using chromatography we have been able to prove that both their distribution among the different plasma proteins and their total concentration in serum and neoplastic tissue are altered. Some differences were found in the values of ceruloplasmin against controls by measuring its oxidizing activity as opposed to O-phenylenediamine. At the same time, using electrophoretic techniques, we have studied the global modifications in the different groups of plasma proteins in neoplastic serum. This report is especially interested in the metabolism of copper, chrome and zinc in serum and tissue in about 20 patients suffering from lung and colorectal neoplasia, in order to compare the parameters which were studied.
我们已经发现了正在经历致癌过程的微量元素代谢变化。通过色谱法，我们能够证明它们在不同血浆蛋白中的分布以及它们在血清和肿瘤组织中的总浓度都发生了改变。通过测量其相对于邻苯二胺的氧化活性，发现与对照组相比，铜蓝蛋白的值存在一些差异。同时，我们使用电泳技术研究了肿瘤血清中不同血浆蛋白组的整体变化。本报告特别关注约20例患有肺癌和结直肠癌的患者血清和组织中铜、铬和锌的代谢情况，以便比较所研究的参数。
