Akhtar S Q
Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Chemotherapy. 1988;34(4):326-31. doi: 10.1159/000238587.
The antimicrobial sensitivity of Campylobacter jejuni isolated in Bangladesh from patients with diarrhoea, asymptomatic carriers and domestic animals was performed. All isolates were sensitive to erythromycin, gentamicin, furazolidone and kanamycin. Seven percent isolates were resistant to tetracycline, 8% to nalidixic acid, 37% to ampicillin and 100% to sulfamethoxazole-trimethoprim and cephalothin. Tetracycline resistance was observed to be plasmid mediated. No plasmid band(s) coding for ampicillin, sulfamethoxazole-trimethoprim or cephalothin resistance were observed, possibly indicating chromosomally located resistance. No significant differences in the susceptibility patterns of C. jejuni isolated from the different sources was observed. However, 10 patients' isolates showed low molecular weight (2-3, 7 Mdaltons) plasmid band(s) which were completely absent in isolates from asymptomatic carriers and animals.
对在孟加拉国从腹泻患者、无症状携带者及家畜中分离出的空肠弯曲菌进行了抗菌敏感性检测。所有分离株对红霉素、庆大霉素、呋喃唑酮和卡那霉素敏感。7%的分离株对四环素耐药，8%对萘啶酸耐药，37%对氨苄西林耐药，100%对磺胺甲恶唑-甲氧苄啶和头孢噻吩耐药。观察到四环素耐药是由质粒介导的。未观察到编码氨苄西林、磺胺甲恶唑-甲氧苄啶或头孢噻吩耐药的质粒条带，这可能表明耐药性位于染色体上。从不同来源分离出的空肠弯曲菌的药敏模式未观察到显著差异。然而，10例患者的分离株显示出低分子量（2 - 3、7兆道尔顿）的质粒条带，而无症状携带者和动物的分离株中则完全没有。
