Lorente Leonardo, Martín María M, Pérez-Cejas Antonia, González-Rivero Agustín F, Abreu-González Pedro, Ramos Luis, Argueso Mónica, Solé-Violán Jordi, Cáceres Juan J, Jiménez Alejandro, García-Marín Victor
Intensive Care Unit, Hospital Universitario de Canarias, 38320 Ofra s/n. La Laguna, Spain.
Intensive Care Unit, Hospital Universitario Nuestra Señora de Candelaria, 38020 Crta del Rosario s/n., Spain.
Brain Sci. 2020 Feb 18;10(2):110. doi: 10.3390/brainsci10020110.
Oxidation is involved in secondary brain injury after traumatic brain injury (TBI). Increased concentrations of total antioxidant capacity (TAC) in blood at the time of admission for TBI have been found in non-surviving patients. The main objective of this study was to determine the role of serum TAC levels at any time during the first week of TBI for the prediction of early mortality.
Isolated (<10 points in non-cranial aspects of Injury Severity Score) and severe (<9 points in Glasgow Coma Scale) TBI patients were included. Serum TAC concentrations at days 1, 4, and 8 of TBI were determined. The end-point study was 30-day mortality.
Higher serum TAC levels at days 1 ( < 0.001), 4 ( < 0.001), and 8 ( = 0.002) of TBI were found in non-surviving ( = 34) than in surviving patients ( = 90). The area under curve (95% Confidence Interval) for prediction of 30-day mortality by serum TAC concentrations at days 1, 4, and 8 of TBI were 0.79 (0.71-0.86; < 0.001), 0.87 (0.79-0.93; < 0.001), and 0.76 (0.67-0.84; = 0.006) respectively.
The novelty of our study was the ability to predict 30-day mortality by serum TAC concentrations at any time during the first week of TBI.
氧化反应参与创伤性脑损伤（TBI）后的继发性脑损伤。在TBI入院时，非存活患者血液中的总抗氧化能力（TAC）浓度有所升高。本研究的主要目的是确定TBI第一周内任何时间的血清TAC水平对早期死亡率预测的作用。
纳入孤立性（损伤严重程度评分非颅脑方面<10分）和重度（格拉斯哥昏迷量表<9分）TBI患者。测定TBI第1天、第4天和第8天的血清TAC浓度。研究终点为30天死亡率。
非存活患者（n = 34）在TBI第1天（P < 0.001）、第4天（P < 0.001）和第8天（P = 0.002）的血清TAC水平高于存活患者（n = 90）。TBI第1天、第4天和第8天血清TAC浓度预测30天死亡率的曲线下面积（95%置信区间）分别为0.79（0.71 - 0.86；P < 0.001）、0.87（0.79 - 0.93；P < 0.001）和0.76（0.67 - 0.84；P = 0.006）。
我们研究的新颖之处在于能够通过TBI第一周内任何时间的血清TAC浓度预测30天死亡率。
