Department of Psychology, Wayne State University, Detroit, MI, USA; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA; Institute of Gerontology, Wayne State University, Detroit, MI, USA; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, 405 North Mathews Avenue, Urbana, IL 61801, USA.
Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, 405 North Mathews Avenue, Urbana, IL 61801, USA; Department of Bioengineering, University of Illinois, Urbana, IL, USA.
Trends Neurosci Educ. 2020 Mar;18:100123. doi: 10.1016/j.tine.2019.100123. Epub 2019 Nov 5.
Fluid intelligence (G) is a critical cognitive ability that is predictive of real-world outcomes, and it has been a persistent aim to characterize its neural architecture.
We advance our prior research by applying latent class analysis to evaluate individual differences in the neural and cognitive foundations of G over the course of a 16-week randomized, multi-modal intervention trial in neurologically healthy, younger adults (N = 424).
Controlling for pre-intervention ability, three latent classes described individual performance at post-intervention and one group (n = 71) showed greater gains in visuospatial reasoning and high performance at post-intervention. The high performance group was predicted by larger anterior cingulate cortex, caudate and hippocampus volumes, and smaller middle frontal, insula and parahippocampal cortex volumes.
Regions that support cognitive control, working memory, and relational processes differentiated individuals who had higher G ability at pre-intervention and demonstrated a cumulative better response to the intervention.
流体智力（G）是一种关键的认知能力，可预测现实世界的结果，其神经结构一直是研究的重点。
我们在前人的研究基础上，通过应用潜在类别分析来评估神经和认知基础在 16 周随机、多模式干预试验中的个体差异，该试验针对的是神经健康的年轻成年人（N=424）。
在控制了干预前的能力后，三种潜在类别描述了个体在干预后的表现，其中一组（n=71）在干预后的视觉空间推理和表现上表现出更大的提高。高表现组的预测指标是前扣带皮层、尾状核和海马体体积较大，而中额、脑岛和海马旁回皮质体积较小。
支持认知控制、工作记忆和关系过程的区域区分了那些在干预前具有更高 G 能力的个体，并表现出对干预的累积更好的反应。
