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Nogo receptor complex expression dynamics in the inflammatory foci of central nervous system experimental autoimmune demyelination.中枢神经系统实验性自身免疫性脱髓鞘炎症病灶中Nogo受体复合物的表达动态
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本文引用的文献

1
A proteolytic C-terminal fragment of Nogo-A (reticulon-4A) is released in exosomes and potently inhibits axon regeneration.神经节苷脂-A（Reticulon-4A）的蛋白水解 C 末端片段在细胞外体中释放，并强烈抑制轴突再生。
J Biol Chem. 2020 Feb 21;295(8):2175-2183. doi: 10.1074/jbc.RA119.009896. Epub 2019 Nov 20.
2
Current knowledge on exosome biogenesis and release.外泌体生物发生和释放的最新知识。
Cell Mol Life Sci. 2018 Jan;75(2):193-208. doi: 10.1007/s00018-017-2595-9. Epub 2017 Jul 21.
3
Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation.少突胶质细胞外泌体对神经元的多方面影响：对神经元放电频率、信号转导和基因调控的影响
Philos Trans R Soc Lond B Biol Sci. 2014 Sep 26;369(1652). doi: 10.1098/rstb.2013.0510.
4
Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.BACE 蛋白酶的功能、治疗潜力和细胞生物学：现状和未来展望。
J Neurochem. 2014 Jul;130(1):4-28. doi: 10.1111/jnc.12715. Epub 2014 Apr 19.
5
Schwann cell-derived exosomes enhance axonal regeneration in the peripheral nervous system.施旺细胞衍生的外泌体增强周围神经系统中的轴突再生。
Glia. 2013 Nov;61(11):1795-806. doi: 10.1002/glia.22558. Epub 2013 Aug 30.
6
Regulation of postsynaptic retrograde signaling by presynaptic exosome release.突触前小泡释放调控突触后逆向信号转导。
Neuron. 2013 Mar 20;77(6):1039-46. doi: 10.1016/j.neuron.2013.01.013.
7
Myelin associated inhibitors: a link between injury-induced and experience-dependent plasticity.髓鞘相关抑制剂：损伤诱导和经验依赖可塑性之间的联系。
Exp Neurol. 2012 May;235(1):43-52. doi: 10.1016/j.expneurol.2011.06.006. Epub 2011 Jun 15.
8
Nogo-A stabilizes the architecture of hippocampal neurons.Nogo-A 稳定海马神经元的结构。
J Neurosci. 2010 Oct 6;30(40):13220-34. doi: 10.1523/JNEUROSCI.1044-10.2010.
9
Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor.由经验驱动的视觉皮层可塑性受髓磷脂和Nogo受体限制。
Science. 2005 Sep 30;309(5744):2222-6. doi: 10.1126/science.1114362.
10
Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation.网织红细胞素家族成员调节β-分泌酶1（BACE1）的活性及淀粉样β肽的生成。
Nat Med. 2004 Sep;10(9):959-65. doi: 10.1038/nm1088. Epub 2004 Aug 1.

Nogo BACE 登上外泌体。

Nogo BACE jumps on the exosome.

机构信息

Department of Neurology and Neurosurgery, Montréal Neurological Institute, Montréal, Québec H3A 2B4, Canada.

Department of Neurology and Neurosurgery, Montréal Neurological Institute, Montréal, Québec H3A 2B4, Canada.

出版信息

J Biol Chem. 2020 Feb 21;295(8):2184-2185. doi: 10.1074/jbc.H120.012745.

DOI:10.1074/jbc.H120.012745
PMID:32086246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7039564/
Abstract

The protein Nogo-A has been widely studied for its role in inhibiting axonal regeneration following injury to the central nervous system, but the mechanism by which the membrane-bound Nogo-A is presented intercellularly is not fully understood. New research suggests that a highly inhibitory fragment of Nogo-A is generated by the amyloid precursor protein protease BACE1 and presented on the membranes of exosomes following spinal cord injury. This finding represents a new mode through which Nogo-A may exert its effects in the central nervous system.

摘要

神经突生长抑制蛋白 Nogo-A 因其在中枢神经系统损伤后抑制轴突再生的作用而被广泛研究，但细胞间呈递膜结合型 Nogo-A 的机制尚不完全清楚。新的研究表明，淀粉样前体蛋白水解酶 BACE1 产生了 Nogo-A 的一个高度抑制性片段，并在脊髓损伤后通过外泌体的膜呈现。这一发现代表了 Nogo-A 可能在中枢神经系统中发挥作用的一种新模式。