81 株拟青霉属和杯霉属真菌的 9 种抗真菌药物的体外活性。
In vitro activities of nine antifungal drugs against 81 Phialophora and Cyphellophora isolates.
机构信息
Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
出版信息
Antimicrob Agents Chemother. 2012 Nov;56(11):6044-7. doi: 10.1128/AAC.01112-12. Epub 2012 Sep 4.
Abstract
Cyphellophora guyanensis (n = 15), other Cyphellophora species (n = 11), Phialophora europaea (n = 43), and other Phialophora species (n = 12) were tested in vitro against nine antifungal drugs. The MIC(90)s across all of the strains (n = 81) were, in increasing order, as follows: posaconazole, 0.063 μg/ml; itraconazole, 0.5 μg/ml; voriconazole, 1 μg/ml; micafungin, 1 μg/ml; terbinafine, 2 μg/ml; isavuconazole, 4 μg/ml; caspofungin, 4 μg/ml; fluconazole, 8 μg/ml; amphotericin B, 16 μg/ml.
摘要
圭亚那 Cyphellophora（n = 15）、其他 Cyphellophora 种（n = 11）、欧洲拟盘多毛孢（n = 43）和其他拟盘多毛孢种（n = 12）在体外对 9 种抗真菌药物进行了测试。所有菌株（n = 81）的 MIC90 按升序排列如下：泊沙康唑，0.063 μg/ml；伊曲康唑，0.5 μg/ml；伏立康唑，1 μg/ml；米卡芬净，1 μg/ml；特比萘芬，2 μg/ml；艾沙康唑，4 μg/ml；卡泊芬净，4 μg/ml；氟康唑，8 μg/ml；两性霉素 B，16 μg/ml。
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