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81 株拟青霉属和杯霉属真菌的 9 种抗真菌药物的体外活性。

In vitro activities of nine antifungal drugs against 81 Phialophora and Cyphellophora isolates.

机构信息

Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

出版信息

Antimicrob Agents Chemother. 2012 Nov;56(11):6044-7. doi: 10.1128/AAC.01112-12. Epub 2012 Sep 4.

DOI:10.1128/AAC.01112-12
PMID:22948876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3486609/
Abstract

Cyphellophora guyanensis (n = 15), other Cyphellophora species (n = 11), Phialophora europaea (n = 43), and other Phialophora species (n = 12) were tested in vitro against nine antifungal drugs. The MIC(90)s across all of the strains (n = 81) were, in increasing order, as follows: posaconazole, 0.063 μg/ml; itraconazole, 0.5 μg/ml; voriconazole, 1 μg/ml; micafungin, 1 μg/ml; terbinafine, 2 μg/ml; isavuconazole, 4 μg/ml; caspofungin, 4 μg/ml; fluconazole, 8 μg/ml; amphotericin B, 16 μg/ml.

摘要

圭亚那 Cyphellophora(n = 15)、其他 Cyphellophora 种(n = 11)、欧洲拟盘多毛孢(n = 43)和其他拟盘多毛孢种(n = 12)在体外对 9 种抗真菌药物进行了测试。所有菌株(n = 81)的 MIC90 按升序排列如下:泊沙康唑,0.063 μg/ml;伊曲康唑,0.5 μg/ml;伏立康唑,1 μg/ml;米卡芬净,1 μg/ml;特比萘芬,2 μg/ml;艾沙康唑,4 μg/ml;卡泊芬净,4 μg/ml;氟康唑,8 μg/ml;两性霉素 B,16 μg/ml。

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