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一种新型转化生长因子-β，即转化生长因子-β3。

A new type of transforming growth factor-beta, TGF-beta 3.

作者信息

Derynck R, Lindquist P B, Lee A, Wen D, Tamm J, Graycar J L, Rhee L, Mason A J, Miller D A, Coffey R J

机构信息

Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080.

出版信息

EMBO J. 1988 Dec 1;7(12):3737-43. doi: 10.1002/j.1460-2075.1988.tb03257.x.

DOI:10.1002/j.1460-2075.1988.tb03257.x
PMID:3208746
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC454948/
Abstract

A new type of TGF-beta, TGF-beta 3, has been identified by cDNA characterization. The amino acid sequence of mature TGF-beta 3 and its precursor has been derived from porcine and human cDNA sequences. The human TGF-beta 3 gene is spread over seven exons as in the case of the TGF-beta 1 gene. Comparison with TGF-beta 1 and -beta 2 indicates a strong conservation of the mature sequences, but a relaxed homology in the precursor segments. TGF-beta 3 mRNA is mainly expressed in cell lines from mesenchymal origin, suggesting a biological role different from the other TGFs-beta.

摘要

一种新型的转化生长因子β（TGF-β），即TGF-β3，已通过cDNA表征得以鉴定。成熟TGF-β3及其前体的氨基酸序列已从猪和人的cDNA序列推导得出。与TGF-β1基因一样，人TGF-β3基因分布在七个外显子上。与TGF-β1和-β2的比较表明，成熟序列具有高度保守性，但前体片段的同源性较低。TGF-β3 mRNA主要在间充质来源的细胞系中表达，这表明其生物学作用与其他TGF-β不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d58/454948/4062f134b926/emboj00149-0116-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d58/454948/06e1428d3fbf/emboj00149-0114-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d58/454948/4062f134b926/emboj00149-0116-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d58/454948/06e1428d3fbf/emboj00149-0114-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d58/454948/4062f134b926/emboj00149-0116-a.jpg

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Thyroid or glucocorticoid hormone induces pre-growth-hormone mRNA and its probable nuclear precursor in rat pituitary cells.甲状腺激素或糖皮质激素可诱导大鼠垂体细胞中的前生长激素信使核糖核酸及其可能的核前体。
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