Derynck R, Lindquist P B, Lee A, Wen D, Tamm J, Graycar J L, Rhee L, Mason A J, Miller D A, Coffey R J
Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080.
EMBO J. 1988 Dec 1;7(12):3737-43. doi: 10.1002/j.1460-2075.1988.tb03257.x.
A new type of TGF-beta, TGF-beta 3, has been identified by cDNA characterization. The amino acid sequence of mature TGF-beta 3 and its precursor has been derived from porcine and human cDNA sequences. The human TGF-beta 3 gene is spread over seven exons as in the case of the TGF-beta 1 gene. Comparison with TGF-beta 1 and -beta 2 indicates a strong conservation of the mature sequences, but a relaxed homology in the precursor segments. TGF-beta 3 mRNA is mainly expressed in cell lines from mesenchymal origin, suggesting a biological role different from the other TGFs-beta.
一种新型的转化生长因子β（TGF-β），即TGF-β3，已通过cDNA表征得以鉴定。成熟TGF-β3及其前体的氨基酸序列已从猪和人的cDNA序列推导得出。与TGF-β1基因一样，人TGF-β3基因分布在七个外显子上。与TGF-β1和-β2的比较表明，成熟序列具有高度保守性，但前体片段的同源性较低。TGF-β3 mRNA主要在间充质来源的细胞系中表达，这表明其生物学作用与其他TGF-β不同。
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