Scherer P W
Chest. 1981 Dec;80(6 Suppl):830-3. doi: 10.1378/chest.80.6.830.
Experiments are described in which a cough is simulated by blowing Newtonian and non-Newtonian liquids out of a straight tube by a turbulent gas flow. Analysis of these experiments indicates that during the flow a steady state balance exists between the shear force exerted on the flowing liquid layer by the flowing gas and the shear force required to maintain the liquid layer in steady laminar flow along the tube wall. By using this steady state shear force balance, quantitative estimates are obtained for the serous layer velocities induced by a cough in various generations of the bronchial tree. These are compared to normal ciliary mucus velocities and are seen to be significant down to about the 12th generation for a cough in a healthy individual. The magnitude of cough-induced serous layer velocities is seen to be strongly dependent on the serous layer thickness, ls, and viscosity, mu s, and increase linearly with ls over mu s.
本文描述了通过湍流气流将牛顿流体和非牛顿流体从直管中吹出以模拟咳嗽的实验。对这些实验的分析表明，在流动过程中，流动气体施加在流动液体层上的剪切力与维持液体层沿管壁稳定层流所需的剪切力之间存在稳态平衡。利用这种稳态剪切力平衡，对咳嗽在支气管树各代中引起的浆液层速度进行了定量估计。将这些估计值与正常纤毛黏液速度进行比较，结果表明，对于健康个体的咳嗽，在大约第12代之前，这些估计值都是显著的。咳嗽引起的浆液层速度大小强烈依赖于浆液层厚度ls和黏度μs，并随ls/μs线性增加。
