Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Vaccine. 2020 Mar 17;38(13):2816-2826. doi: 10.1016/j.vaccine.2020.02.017. Epub 2020 Feb 19.
Incidence and mortality of human papillomavirus (HPV)-related cancers differs geographically, with high rates in Caribbean countries. Seroepidemiological data provide information on lifetime cumulative HPV exposure and contributing risk factors, but has not been available yet for Caribbean Netherlands (CN), comprising the islands Bonaire, St. Eustatius and Saba. Therefore, a cross-sectional population-based serosurveillance study was performed in this (recently girls-only HPV-vaccinated) population in 2017.
Blood samples from participants (n = 1,823, 0-90 years) were tested for seven high-risk (hr)-HPV-specific IgG-antibodies using a VLP-based multiplex-immunoassay. Risk factors for HPV-seropositivity were analysed among persons unvaccinated aged ≥ 15 years who ever had sex (n = 1,080).
Among unvaccinated individuals aged ≥ 15 years, overall seropositivity was high (34%), with over half of them being seropositive for ≥ 2 hr-HPV types, and HPV16 and 52 being most prevalent (13%). Seroprevalence was substantial higher in unvaccinated women (51%) than men (18%), predominantly peaking in women aged 20-59 years, and was highest on St. Eustatius (38%). Besides age and sex, sexual risk factors were associated with HPV-seropositivity.
In accordance with the Caribbean region, seroprevalence of multiple hr-HPV types was high in CN. These data corroborate the decision regarding introduction of a sex-neutral HPV-vaccination program and the relevance for considering a population-based cervical cancer screening program.
人乳头瘤病毒（HPV）相关癌症的发病率和死亡率在地理位置上存在差异，加勒比国家的发病率较高。血清流行病学数据提供了关于一生中 HPV 暴露的信息和相关的危险因素，但在加勒比荷兰（包括博内尔岛、圣尤斯特歇斯岛和萨巴岛）尚未获得。因此，在 2017 年对该（最近仅对女孩进行 HPV 疫苗接种）人群进行了一项基于人群的横断面血清学监测研究。
对来自参与者（n=1823，0-90 岁）的血液样本进行了七种高危（hr）-HPV 特异性 IgG 抗体的检测，使用基于 VLP 的多重免疫分析。对未接种疫苗且≥15 岁有过性行为的人群（n=1080）进行了 HPV 血清阳性的危险因素分析。
在未接种疫苗且≥15 岁的人群中，总体血清阳性率较高（34%），其中超过一半的人对≥2 种 hr-HPV 类型呈血清阳性，HPV16 和 52 最为常见（13%）。未接种疫苗的女性（51%）比男性（18%）的血清阳性率高得多，主要在 20-59 岁女性中达到高峰，圣尤斯特歇斯岛（38%）的血清阳性率最高。除了年龄和性别，性危险因素与 HPV 血清阳性相关。
与加勒比地区一致，CN 中多种高危型 HPV 的血清流行率较高。这些数据证实了引入中性性别 HPV 疫苗接种计划的决定，以及考虑开展基于人群的宫颈癌筛查计划的相关性。
