Sun Lingyan, Li Li, Xu Wenxin, Ma Cen
Department of Obstetrics and Gynecology Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215000, China.
Galen Med J. 2023 May 20;12:e2991. doi: 10.31661/gmj.v12i0.2991. eCollection 2023.
Evidence suggests the role of the vaginal microbiome and microenvironment in the immunity state. The human papillomavirus (HPV) infection is widely dependent on the healthy vaginal microenvironment. Hence, this study aimed to investigate the role of the vaginal microenvironment in the rate of high-risk HPV (hr-HPV) infection.
This cross-sectional study was performed on 512 women with hr-HPV positive (n=212) or negative (n=300) infection. The vaginal samples of women were examined regarding yeas and Gardnerella vaginalis infection. Also, Lactobacillus acidophilus, pH, and enzyme activity (such as catalase, proline aminopeptidase, and leucocyte esterase) were compared between the two groups. Also, the histopathological study was performed on the vaginal samples.
The higher rate of yeast and G. vaginalis infections as well as decreased L. acidophilus, were significantly observed in women with hr-HPV positive infection (P0.001). Also, histopathological findings indicated that cervical intraepithelial neoplasia grade I-III and cervical cancer lesions were markedly higher in hr-HPV positive group compared with control women.
The hr-HPV infection was markedly correlated to vaginal microenvironments, and it could a risk factor for the elevation of the rate of high-grade cervical lesions.
有证据表明阴道微生物群和微环境在免疫状态中发挥作用。人乳头瘤病毒（HPV）感染广泛依赖于健康的阴道微环境。因此，本研究旨在调查阴道微环境在高危型HPV（hr-HPV）感染率中的作用。
本横断面研究对512名hr-HPV感染阳性（n=212）或阴性（n=300）的女性进行。检查女性阴道样本是否存在酵母菌和阴道加德纳菌感染。此外，比较了两组之间嗜酸乳杆菌、pH值和酶活性（如过氧化氢酶、脯氨酸氨基肽酶和白细胞酯酶）。同时，对阴道样本进行了组织病理学研究。
在hr-HPV阳性感染的女性中，显著观察到酵母菌和阴道加德纳菌感染率较高，以及嗜酸乳杆菌减少（P<0.001）。此外，组织病理学结果表明，与对照女性相比，hr-HPV阳性组中宫颈上皮内瘤变I-III级和宫颈癌病变明显更高。
hr-HPV感染与阴道微环境显著相关，并且它可能是高级别宫颈病变发生率升高的一个危险因素。
