Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, Hunan Province, PR China.
Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, Hunan Province, PR China.
Int J Biol Macromol. 2020 May 15;151:757-780. doi: 10.1016/j.ijbiomac.2020.02.217. Epub 2020 Feb 20.
The knowledge on the mechanisms of DNA interfacing with nanoparticles holds great potential for the design, assembly and usage of DNA in biological applications. A wave of understanding and exploitation of the mechanisms in DNA-nanoparticles interfacial phenomenon has raised. Although some previous reviews have been reported, systematic and detailed reviews are rare. To achieve a better understanding of the mechanisms in the interaction between DNA and nanoparticles, here, we summarized the recent progresses on the fundamental principles regarding the DNA-nanoparticle interactions and their applications in biosensing. Special focus was put on inorganic nanoparticles such as metal nanoparticles, carbon-based materials, metal oxides and quantum dots. For each material, the surface properties, the interfacing mechanisms, and the kinetics and spatial control of DNA adsorption were summarized and discussed. We also highlighted some of the recent technologies based on DNA-NPs interactions for biomolecules detection. Finally, the challenges and future directions were discussed and proposed. This review provides a systematic understanding of the mechanisms in the interaction of DNA-nanoparticles, which, in turn, can inspire new insights for designing biosensors with improved properties.
DNA 与纳米颗粒相互作用机制的知识对于 DNA 在生物应用中的设计、组装和使用具有巨大的潜力。人们对 DNA-纳米颗粒界面现象的机制的理解和利用掀起了一波浪潮。尽管已经有一些综述报道，但系统而详细的综述却很少见。为了更好地理解 DNA 与纳米颗粒相互作用的机制，在这里，我们总结了 DNA-纳米颗粒相互作用的基本原理及其在生物传感中的应用的最新进展。特别关注了金属纳米颗粒、碳基材料、金属氧化物和量子点等无机纳米颗粒。对于每种材料，我们总结和讨论了其表面特性、界面作用机制、DNA 吸附的动力学和空间控制。我们还强调了一些基于 DNA-NPs 相互作用的用于生物分子检测的新技术。最后，讨论并提出了挑战和未来方向。本综述提供了对 DNA-纳米颗粒相互作用机制的系统理解，这反过来又可以为设计具有改进性能的生物传感器提供新的见解。
