Department of Radiology, The Third Hospital of Hebei Medical University, 139 Ziqiang Road, Shijiazhuang, 050051, Hebei Province, China.
Arch Osteoporos. 2020 Feb 22;15(1):18. doi: 10.1007/s11657-020-0682-2.
We found that the MRI T2* value is moderately negatively correlated with the bone mineral density assessed with quantitative computed tomography in evaluating osteoporosis in postmenopausal women and may have some potential in assessing severity of lumbar osteoporosis for scientific research.
To investigate the T2* quantitative measurement in magnetic resonance imaging (MRI) and its correlation with the bone mineral density (BMD) values evaluated with quantitative computed tomography (QCT) in women with postmenopausal lumbar vertebrae osteoporosis.
Eighty-seven postmenopausal women were enrolled who had MRI scanning with T1WI, T2WI, and T2* mapping sequences and QCT evaluation of BMD. The T2* value and the BMD were assessed in lumbar vertebral bodies 2-4. Based on the BMD values, the patients were divided into three groups: normal, osteopenia, and osteoporosis.
The inter- and intra-observer intraclass correlation coefficients (ICCs) for T2* were 0.91 (0.87-0.94, 95% CI) and 0.93 (0.88-0.95, 95% CI), respectively. The inter- and intra-observer ICCs for the BMD value were 0.89 (0.83-0.92, 95% CI) and 0.91 (0.86-0.93, 95% CI), respectively. The differences of the T2* values and BMD among the three groups were statistically significant (P < 0.05). The BMD value was greater in the normal group (145.02 ± 18.94 mg/cm) than the other two groups (97.90 ± 16.18 mg/cm for osteopenia and 59.09 ± 18.71 mg/cm for osteoporosis). The normal group had a significantly (P < 0.05) smaller T2* value than the other two groups (8.39 ± 4.17 ms in the normal group versus 12.25 ± 3.36 ms in the osteopenia or 15.54 ± 4.9 ms in the osteoporosis). A significant (P < 0.05) difference also existed in the T2* value between the osteopenia and the osteoporosis groups. The correlations of the T2* values with BMD values were significantly (P < 0.05) negative after adjusting for age (r = - 0.33, - 0.45, and - 0.51 for normal, osteopenia, and osteoporosis, respectively).
The MRI T2*value is moderately negatively correlated with the bone mineral density assessed with quantitative computed tomography in evaluating osteoporosis in postmenopausal women and may have some potential in assessing severity of lumbar osteoporosis for scientific research.
探讨绝经后女性腰椎骨质疏松症患者磁共振成像（MRI）T2*定量测量及其与定量计算机断层扫描（QCT）评估骨密度（BMD）值的相关性。
对 87 例绝经后女性进行 MRI T1WI、T2WI 和 T2mapping 序列扫描及 QCT 评估 BMD，测量并比较腰椎 2-4 椎体 T2值和 BMD 值。根据 BMD 值将患者分为正常组、骨量减少组和骨质疏松组。
T2值的组内和组间观察者间 ICC 分别为 0.91（0.87-0.94，95%CI）和 0.93（0.88-0.95，95%CI），BMD 值的组内和组间观察者间 ICC 分别为 0.89（0.83-0.92，95%CI）和 0.91（0.86-0.93，95%CI）。三组间 T2值和 BMD 值差异均有统计学意义（P<0.05）。正常组 BMD 值[（145.02±18.94）mg/cm]明显高于其他两组[骨量减少组为（97.90±16.18）mg/cm，骨质疏松组为（59.09±18.71）mg/cm]。正常组 T2值明显小于其他两组[（8.39±4.17）ms，骨量减少组为（12.25±3.36）ms，骨质疏松组为（15.54±4.9）ms]，差异均有统计学意义（P<0.05）。骨量减少组与骨质疏松组间 T2值也有显著差异（P<0.05）。校正年龄后，T2*值与 BMD 值的相关性均有统计学意义（正常组 r=-0.33、-0.45、-0.51，骨量减少组 r=-0.33、-0.45、-0.51，骨质疏松组 r=-0.33、-0.45、-0.51）。
MRI T2*值与绝经后女性 QCT 评估的骨密度值呈中度负相关，在科学研究中可能具有评估腰椎骨质疏松严重程度的潜力。
