Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 32611, USA.
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 32611, USA.
Redox Biol. 2020 Aug;35:101462. doi: 10.1016/j.redox.2020.101462. Epub 2020 Feb 20.
Endurance exercise training promotes numerous biochemical adaptations within skeletal muscle fibers culminating into a phenotype that is safeguarded against numerous perils including doxorubicin-induced myopathy and inactivity-induced muscle atrophy. This exercise-induced protection of skeletal muscle fibers is commonly termed "exercise preconditioning". This review will discuss the biochemical mechanisms responsible for exercise-induced protection of skeletal muscle fibers against these harmful events. The first segment of this report highlights the evidence that endurance exercise training provides cytoprotection to skeletal muscle fibers against several potentially damaging insults. The second and third sections of the review will discuss the cellular adaptations responsible for exercise-induced protection of skeletal muscle fibers against doxorubicin-provoked damage and inactivity-induced fiber atrophy, respectively. Importantly, we also identify gaps in our understanding of exercise preconditioning in hopes of stimulating future research.
耐力运动训练促进了骨骼肌纤维内许多生化适应，最终形成一种表型，这种表型可以预防许多危险，包括阿霉素诱导的肌病和不活动引起的肌肉萎缩。这种运动引起的骨骼肌纤维保护通常被称为“运动预处理”。本综述将讨论生化机制负责运动诱导的骨骼肌纤维免受这些有害事件的保护。本报告的第一部分强调了耐力运动训练为骨骼肌纤维提供细胞保护，防止几种潜在的损伤性刺激的证据。综述的第二和第三部分将分别讨论细胞适应性，负责运动诱导的保护骨骼肌纤维免受阿霉素引起的损伤和不活动引起的纤维萎缩。重要的是，我们还确定了我们对运动预处理理解中的差距，希望能激发未来的研究。
