孕酮拮抗剂RU486（米非司酮）在孕早期流产术前宫颈扩张中的疗效。

Efficacy of progesterone antagonist RU486 (mifepristone) for pre-operative cervical dilatation during first trimester abortion.

作者信息

Durlot F, Dubois C, Brunerie J, Frydman R

机构信息

Service de Gynécologie Obstétrique, Hôpital Antoine Béclère, Clamart, France.

出版信息

Hum Reprod. 1988 Jul;3(5):583-4. doi: 10.1093/oxfordjournals.humrep.a136749.

DOI:10.1093/oxfordjournals.humrep.a136749

PMID:3170699

Abstract

A randomized double-blind study (RU486 versus placebo) was carried out in order to investigate whether a progesterone antagonist facilitated surgical abortion in the first trimester of pregnancy. The consistency of the cervix changed significantly after RU486 (P less than 0.02). We conclude that this effect may facilitate cervical dilatation, making first trimester abortion under local anaesthesia more comfortable and less dangerous.

摘要

为了研究孕酮拮抗剂是否有助于妊娠早期的人工流产，进行了一项随机双盲研究（米非司酮与安慰剂对照）。服用米非司酮后宫颈的顺应性有显著变化（P<0.02）。我们得出结论，这种作用可能有助于宫颈扩张，使局部麻醉下的早期流产更舒适且危险性更低。