Scofield R Hal, Fayyaz Anum, Kurien Biji T, Koelsch Kristi A
Arthritis & Clinical Immunol Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
J Lab Precis Med. 2018 Oct;3. doi: 10.21037/jlpm.2018.08.05. Epub 2018 Oct 30.
Sjögren's syndrome is in part considered an autoimmune disease because patient sera contain antibodies binding self-structures. In fact, in addition to anti-Ro (or SSA) and anti-La (or SSB), which are included in the classification criteria, there are a wide variety of autoantibodies found among these patients. We reviewed English-language MEDLINE sources. Anti-Ro and anti-La found among healthy individuals, including mothers giving birth to infants with neonatal lupus, predicts future connective tissue disease. Those with Sjögren's syndrome can be divided into two groups; patients with only exocrine gland involvement and those with systemic disease. The presence of anti-Ro/La is associated with systemic, extraglandular disease. Rheumatoid factor is also associated with extraglandular disease while anti-cyclic citrullinated peptide (CCP) is likely associated with inflammatory arthritis and progression to rheumatoid arthritis. Anti-mitochondrial antibodies are uncommon but predict progression to primary biliary cirrhosis. Cryoglobulinemia is found in excess among those with non-Hodgkin's lymphoma. Determination of autoantibodies on the sera of Sjögren's syndrome patients has prognostic implications for Sjögren's syndrome itself as well as associated diseases.
干燥综合征在一定程度上被认为是一种自身免疫性疾病，因为患者血清中含有能结合自身结构的抗体。事实上，除了分类标准中包含的抗Ro（或SSA）和抗La（或SSB）之外，在这些患者中还发现了各种各样的自身抗体。我们查阅了英文的MEDLINE资料来源。在健康个体中发现的抗Ro和抗La，包括生育患有新生儿狼疮婴儿的母亲，可预测未来的结缔组织疾病。干燥综合征患者可分为两组；仅累及外分泌腺的患者和患有系统性疾病的患者。抗Ro/La的存在与系统性、腺体外疾病有关。类风湿因子也与腺体外疾病有关，而抗环瓜氨酸肽（CCP）可能与炎症性关节炎及进展为类风湿关节炎有关。抗线粒体抗体不常见，但可预测进展为原发性胆汁性肝硬化。冷球蛋白血症在非霍奇金淋巴瘤患者中更为常见。检测干燥综合征患者血清中的自身抗体对干燥综合征本身以及相关疾病具有预后意义。
