"Petru Poni" Institute of Macromolecular Chemistry, 41-A Grigore Ghica Voda Alley, RO-700487, Iasi, Romania.
Macromol Biosci. 2020 Apr;20(4):e1900412. doi: 10.1002/mabi.201900412. Epub 2020 Feb 24.
The purpose of the study is to obtain multicomponent polyelectrolyte hydrogels with optimal synergistic properties by combining a modified starch with a synthetic one. Thus, new low-cost and biocompatible semi-interpenetrating polymer network (semi-IPN) hydrogels of carboxymethyl starch and poly(2-dimethylaminoethyl methacrylate) are prepared and investigated. The synthesized hydrogels are studied with respect to the specific characteristics of the gels: swelling kinetics, thermal analysis, viscoelastic characteristics, and their ability to be used as a matrix in drug delivery systems. Therefore, the semi-IPN gels are loaded with ibuprofen, followed by additional tests to assess the in vitro drug release. The cytocompatibility of the hydrogels with respect to their composition is evaluated in vitro on fibroblast cell culture. The investigations confirm the obtainment of new semi-IPN hydrogels with pH and temperature responsiveness, good mechanical strength, and potential for use as drug delivery systems or transdermal patches.
本研究的目的是通过将改性淀粉与合成物相结合，获得具有最佳协同性能的多组分聚电解质水凝胶。因此，我们制备并研究了新型低成本、生物相容的羧甲基淀粉和聚（2-二甲氨基乙基甲基丙烯酸酯）半互穿聚合物网络（semi-IPN）水凝胶。针对凝胶的特定特性对合成水凝胶进行了研究：溶胀动力学、热分析、粘弹性特性以及它们作为药物传递系统基质的能力。因此，将半互穿聚合物网络凝胶负载布洛芬，然后进行额外的测试以评估体外药物释放。水凝胶的细胞相容性通过体外成纤维细胞培养进行评估。研究证实获得了具有 pH 和温度响应性、良好机械强度以及用作药物传递系统或透皮贴剂的潜力的新型半互穿聚合物网络水凝胶。
