Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China.
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.
Obesity (Silver Spring). 2020 Mar;28(3):601-608. doi: 10.1002/oby.22731.
The aim of this study was to investigate alterations in functional connectivity (FC) within and interactions between resting-state networks involved in salience, executive control, and interoception in participants with obesity (OB).
Using resting-state functional magnetic resonance imaging with independent component analysis and FC, alterations within and interactions between resting-state networks in 35 OB and 35 normal-weight controls (NW) were investigated.
Compared with NW, OB showed reduced FC strength in the ventromedial prefrontal cortex and posterior cingulate cortex/precuneus within the default-mode network, dorsal anterior cingulate cortex within the salience network (SN), bilateral dorsolateral prefrontal cortex-angular gyrus within the frontoparietal network (FPN), and increased FC strength in the insula (INS) (P < 0.0125). The dorsal anterior cingulate cortex FC strength was negatively correlated with craving for food cues, left dorsolateral prefrontal cortex FC strength was negatively correlated with Yale Food Addiction Scale scores, and right INS FC strength was positively correlated with craving for high-calorie food cues. Compared with NW, OB also showed increased FC between the SN and FPN driven by altered FC of bilateral INS and anterior cingulate cortex-angular gyrus.
Alterations in FC within and interactions between the SN, default-mode network, and FPN might contribute to the high incentive value of food (craving), lack of control of overeating (compulsive overeating), and increased awareness of hunger (impaired interoception) in OB.
本研究旨在探究肥胖症（OB）患者中与突显、执行控制和内脏感知相关的静息态网络内及网络间的功能连接（FC）改变。
采用静息态功能磁共振成像和独立成分分析及 FC，研究了 35 名 OB 患者和 35 名正常体重对照（NW）者静息态网络内及网络间的改变。
与 NW 相比，OB 患者默认模式网络中腹内侧前额叶皮质和后扣带回/楔前叶、突显网络中背侧前扣带皮质、额顶叶网络中双侧背外侧前额叶-角回以及岛叶（INS）的 FC 强度降低（P < 0.0125）。背侧前扣带皮质的 FC 强度与食物线索的渴望呈负相关，左背外侧前额叶 FC 强度与耶鲁食物成瘾量表评分呈负相关，右 INS 的 FC 强度与高热量食物线索的渴望呈正相关。与 NW 相比，OB 患者的 SN 和 FPN 之间的 FC 也增加了，这是由双侧 INS 和前扣带皮质-角回的 FC 改变驱动的。
SN、默认模式网络和 FPN 内及网络间的 FC 改变可能导致 OB 患者对食物（渴望）具有较高的激励价值、对暴食（强迫性暴食）缺乏控制以及对饥饿（内脏感知受损）的意识增加。
