Li Yuqin, Yang Qian, Liu Yuxin, Zheng Yutong, Li Jianfu, Chen Chunli, Chen Baodan, Yao Dezhong, Yu Liang, Xu Peng, Li Fali, Liang Yi
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and TechnologyUniversity of Electronic Science and Technology of China Chengdu 611731 China.
Research Unit of NeuroInformationChinese Academy of Medical Sciences Chengdu 2019RU035 China.
IEEE Open J Eng Med Biol. 2024 Jul 11;5:783-791. doi: 10.1109/OJEMB.2024.3425855. eCollection 2024.
. Until now, limited knowledge remains regarding the association among childhood obesity, cognitive behavior, and brain networks. Utilizing a publicly available dataset, we aimed to investigate the relationships between childhood obesity and functional networks during the stop-signal task. . Given the huge conflict-monitoring and inhibitory control demands of the task, both enhanced network connectivity and properties were observed under the "No-go" compared to the "Go" condition for both obese and non-obese preadolescents. Obese preadolescents exhibited significantly increased frontal-parietal, frontal-occipital, and frontal-temporal linkages, as well as heightened network efficiency under both "Go" and "No-go" conditions compared to non-obese counterparts. Additionally, significant correlations were found between network connectivity and properties and preadolescents' body mass index (BMI), with their combination predicting BMI scores successfully. . These findings support that childhood obesity is not simply a deviant habit with restricted physical health consequences, but rather associated with the atypical development of frontal-based networks involved in inhibitory control and cognitive performance.
到目前为止，关于儿童肥胖、认知行为和脑网络之间的关联，我们所知有限。利用一个公开可用的数据集，我们旨在研究在停止信号任务期间儿童肥胖与功能网络之间的关系。鉴于该任务对冲突监测和抑制控制有巨大需求，在“不执行”条件下，肥胖和非肥胖的青春期前儿童相比“执行”条件下，均观察到网络连通性和属性增强。与非肥胖的同龄人相比，肥胖的青春期前儿童在“执行”和“不执行”条件下，额顶叶、额枕叶和额颞叶的联系均显著增加，网络效率也更高。此外，发现网络连通性和属性与青春期前儿童的体重指数（BMI）之间存在显著相关性，二者结合能够成功预测BMI分数。这些发现表明，儿童肥胖不仅仅是一种具有有限身体健康后果的异常习惯，而是与参与抑制控制和认知表现的额叶网络的非典型发育有关。
