Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, No. 10 Xitoutiao, You'anmenWai, Fengtai District, Beijing, 100069, China.
Municipal Key Laboratory of Clinical Epidemiology, Beijing, 100069, China.
Hormones (Athens). 2023 Sep;22(3):457-466. doi: 10.1007/s42000-023-00462-6. Epub 2023 Jul 10.
Recently, circadian syndrome (CircS) has been proposed as a new predictor of cardiometabolic risk. We aimed to investigate the relationship between the hypertriglyceridemic-waist phenotype and its dynamic status with CircS in China. We conducted a two-stage study based on the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2015. Multivariate logistic regression models in cross-sectional analysis and Cox proportional hazards regression models in longitudinal analysis were used to estimate the associations of hypertriglyceridemic-waist phenotypes with CircS and its components. We then applied multiple logistic regression analysis to evaluate the odds ratios (ORs) and 95% confidence intervals (CIs) for CircS risk by transformation into the hypertriglyceridemic-waist phenotype. A total of 9863 participants were included in the cross-sectional analysis and 3884 participants in the longitudinal analysis. Compared with normal waist circumference (WC) and normal triglyceride (TG) level (NWNT), CircS risk was increased with enlarged WC and high TG level (EWHT) (hazard ratio (HR) 3.87 [95% CI: 2.38, 5.39]). Similar results were observed in subgroup analyses by sex, age, smoking status, and drinking status. During follow-up, CircS risk was increased in group K (stable EWNT during follow-up) (OR 9.97 [95% CI: 6.41, 15.49]) compared with group A (stable NWNT during follow-up), while group L (baseline enlarged WC and normal TG level transformed to follow-up EWHT) had the highest risk of CircS (OR 116.07 [95% CI: 72.77, 185.14]). In conclusion, the hypertriglyceridemic-waist phenotype and its dynamic status were associated with the risk of developing CircS in Chinese adults.
最近，昼夜节律紊乱综合征（CircS）被提出作为一种新的心代谢风险预测因子。我们旨在研究中国高甘油三酯腰围表型及其动态状态与 CircS 之间的关系。我们基于 2011 年至 2015 年的中国健康与退休纵向研究（CHARLS）进行了一项两阶段研究。在横断面分析中使用多变量逻辑回归模型，在纵向分析中使用 Cox 比例风险回归模型来估计高甘油三酯腰围表型与 CircS 及其成分之间的关联。然后，我们应用多元逻辑回归分析通过转化为高甘油三酯腰围表型来评估 CircS 风险的比值比（OR）和 95％置信区间（CI）。共有 9863 名参与者纳入横断面分析，3884 名参与者纳入纵向分析。与正常腰围（WC）和正常甘油三酯（TG）水平（NWNT）相比，WC 增大和 TG 水平升高（EWHT）时 CircS 风险增加（危险比（HR）3.87 [95％CI：2.38，5.39]）。在按性别、年龄、吸烟状况和饮酒状况进行的亚组分析中观察到了类似的结果。在随访期间，与持续存在 NWNT 的组 A 相比，CircS 风险在持续存在 EWNT 的组 K 中增加（OR 9.97 [95％CI：6.41，15.49]），而组 L（基线 WC 增大和正常 TG 水平在随访期间转变为 EWHT）的 CircS 风险最高（OR 116.07 [95％CI：72.77，185.14]）。总之，高甘油三酯腰围表型及其动态状态与中国成年人 CircS 发病风险相关。
