IEEE Trans Med Imaging. 2020 Sep;39(9):2782-2793. doi: 10.1109/TMI.2020.2975347. Epub 2020 Feb 21.
Multi-organ segmentation is a challenging task due to the label imbalance and structural differences between different organs. In this work, we propose an efficient cascaded V-Net model to improve the performance of multi-organ segmentation by establishing dense Block Level Skip Connections (BLSC) across cascaded V-Net. Our model can take full advantage of features from the first stage network and make the cascaded structure more efficient. We also combine stacked small and large kernels with an inception-like structure to help our model to learn more patterns, which produces superior results for multi-organ segmentation. In addition, some small organs are commonly occluded by large organs and have unclear boundaries with other surrounding tissues, which makes them hard to be segmented. We therefore first locate the small organs through a multi-class network and crop them randomly with the surrounding region, then segment them with a single-class network. We evaluated our model on SegTHOR 2019 challenge unseen testing set and Multi-Atlas Labeling Beyond the Cranial Vault challenge validation set. Our model has achieved an average dice score gain of 1.62 percents and 3.90 percents compared to traditional cascaded networks on these two datasets, respectively. For hard-to-segment small organs, such as the esophagus in SegTHOR 2019 challenge, our technique has achieved a gain of 5.63 percents on dice score, and four organs in Multi-Atlas Labeling Beyond the Cranial Vault challenge have achieved a gain of 5.27 percents on average dice score.
多器官分割是一项具有挑战性的任务,因为不同器官之间存在标签不平衡和结构差异。在这项工作中,我们提出了一种有效的级联 V-Net 模型,通过在级联 V-Net 之间建立密集的块级跳过连接 (BLSC) 来提高多器官分割的性能。我们的模型可以充分利用来自第一阶段网络的特征,并使级联结构更加高效。我们还结合了堆叠的小核和大核以及类似于 inception 的结构,帮助我们的模型学习更多的模式,从而为多器官分割产生更好的结果。此外,一些小器官通常被大器官遮挡,并且与周围组织的边界不清晰,这使得它们难以分割。因此,我们首先通过多类网络定位小器官,并随机裁剪它们与周围区域,然后使用单类网络对它们进行分割。我们在 SegTHOR 2019 挑战赛未见过的测试集和多图谱标注超越颅顶挑战验证集上评估了我们的模型。与这两个数据集上的传统级联网络相比,我们的模型在这两个数据集上的平均骰子得分分别提高了 1.62%和 3.90%。对于难以分割的小器官,例如 SegTHOR 2019 挑战赛中的食管,我们的技术在骰子得分上提高了 5.63%,而多图谱标注超越颅顶挑战中的四个器官的平均骰子得分提高了 5.27%。