Jichi Medical University School of Medicine, Shimotsuke, Japan.
Minamisanriku Hospital, Motoyoshigun, Japan.
J Clin Hypertens (Greenwich). 2020 Mar;22(3):465-474. doi: 10.1111/jch.13764. Epub 2020 Feb 24.
Vascular biomarkers, including the cardio-ankle vascular index (CAVI), are increasingly being recognized as important indicators of cardiovascular risk. CAVI has been shown to have good discriminative ability for detecting new-onset hypertension, but results of studies investigating cardiovascular risk prediction are inconsistent. Furthermore, there is a lack of data on the prognostic value of changes in CAVI over time. The Cardiovascular Prognostic Coupling study was designed to determine the impact of baseline CAVI and changes in CAVI on cardiovascular events in a Japanese cohort. The design of the ongoing, multicenter, prospective, observational registry and baseline characteristics of the enrolled population are reported. Eligible consecutive patients were aged ≥30 years, had ≥1 cardiovascular risk factor, and were being treated according to relevant Japanese guidelines. The primary outcome is time to onset of a major cardiovascular event (a composite of cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage, stroke of unknown etiology, myocardial infarction, cardiovascular intervention for angina pectoris, and sudden death). Screening and enrollment occurred over a period of 3 years, followed by ≥7 years of follow-up, with CAVI determined annually. A total of 5279 patients were registered, of whom 5109 had baseline data available and will be included in future analyses. Mean CAVI at baseline was 8.8 ± 1.4. The proportion of patients with CAVI of <8, 8-10 or >10 was 25.3%, 57.0%, and 17.7%, respectively. Data from this registry should provide information on the significance of baseline CAVI and change in CAVI as indicators of cardiovascular prognosis in a representative patient population.
血管生物标志物，包括心踝血管指数（CAVI），越来越被认为是心血管风险的重要指标。CAVI 已被证明对检测新发高血压具有良好的鉴别能力，但研究心血管风险预测的结果不一致。此外，关于 CAVI 随时间变化的预后价值的数据缺乏。心血管预后关联研究旨在确定基线 CAVI 和 CAVI 变化对日本队列心血管事件的影响。报告了正在进行的、多中心、前瞻性、观察性登记研究的设计和纳入人群的基线特征。符合条件的连续患者年龄≥30 岁，有≥1 个心血管危险因素，并根据相关日本指南进行治疗。主要结局是主要心血管事件（脑梗死、脑出血、蛛网膜下腔出血、原因不明的中风、心肌梗死、心绞痛心血管介入治疗和猝死的复合事件）的发病时间。筛选和登记持续了 3 年，随后进行了≥7 年的随访，每年测定一次 CAVI。共登记了 5279 例患者，其中 5109 例有基线数据，将纳入未来的分析。基线时 CAVI 的平均值为 8.8±1.4。CAVI<8、8-10 或>10 的患者比例分别为 25.3%、57.0%和 17.7%。该登记处的数据应提供有关基线 CAVI 和 CAVI 变化作为代表性患者人群心血管预后指标的意义的信息。
