Dolovich M B, Killian D, Wolff R K, Obminski G, Newhouse M T
Am Rev Respir Dis. 1977 Mar;115(3):397-402. doi: 10.1164/arrd.1977.115.3.397.
Quiet breathing by mouth of a 3-mum aerosol was compared with intermittent positive pressure delivery of the same aerosol to the lung in a group of bronchitics. The pattern of lung deposition and the total dose delivered to the lung were measured. The differences between quiet breathing and intermittent positive pressure breathing were found not to be significant (P greater than 0.5). In addition, during similar or greater total ventilation, intermittent positive pressure breathing delivered a mean of 32% less aerosol to the lung than did quiet breathing. These findings suggest that intermittent positive pressure breathing as currently used for aerosol delivery cannot be expected to enhance peripheral deposition of inhaled aerosols in patients with airway obstruction.
在一组支气管炎患者中，对通过口腔平静呼吸3微米气雾剂与向肺部间歇性正压输送相同气雾剂的情况进行了比较。测量了肺部沉积模式和输送到肺部的总剂量。发现平静呼吸和间歇性正压呼吸之间的差异不显著（P大于0.5）。此外，在总通气量相似或更大的情况下，间歇性正压呼吸输送到肺部的气雾剂平均比平静呼吸少32%。这些发现表明，目前用于气雾剂输送的间歇性正压呼吸预计无法增强气道阻塞患者吸入气雾剂的外周沉积。
