Department of Molecular Neurochemistry, Medical University of Lodz, 92-216 Lodz, Poland.
Int J Mol Sci. 2020 Feb 20;21(4):1428. doi: 10.3390/ijms21041428.
Neurodegenerative and mood disorders represent growing medical and social problems, many of which are provoked by oxidative stress, disruption in the metabolism of various neurotransmitters, and disturbances in calcium homeostasis. Biologically active plant compounds have been shown to exert a positive impact on the function of calcium in the central nervous system.
The present paper reviews studies of naturally occurring terpenes and derivatives and the calcium-based aspects of their mechanisms of action, as these are known to act upon a number of targets linked to neurological prophylaxis and therapy.
Most of the studied phytochemicals possess anticancer, antioxidative, anti-inflammatory, and neuroprotective properties, and these have been used to reduce the risk of or treat neurological diseases.
The neuroprotective actions of some phytochemicals may employ mechanisms based on regulation of calcium homeostasis and should be considered as therapeutic agents.
神经退行性和情绪障碍是日益严重的医学和社会问题，其中许多是由氧化应激、各种神经递质代谢紊乱和钙稳态失调引起的。生物活性植物化合物已被证明对中枢神经系统中钙的功能具有积极影响。
本文综述了天然萜类化合物及其衍生物的研究，并探讨了其作用机制中的钙相关方面，因为这些化合物已知作用于与神经预防和治疗相关的多个靶点。
大多数研究的植物化学物质具有抗癌、抗氧化、抗炎和神经保护特性，这些特性已被用于降低患神经疾病的风险或治疗神经疾病。
一些植物化学物质的神经保护作用可能采用基于钙稳态调节的机制，应将其视为治疗剂。
