人类胎儿生长中的内分泌干扰化学品。
Endocrine-Disrupting Chemicals in Human Fetal Growth.
机构信息
Department of Mother and Child, 42123 Azienda USL-IRCCS di Reggio Emilia, Italy.
Microbiome Research Hub, University of Parma, Via A. Catalani 10, 43123 Parma, Italy.
出版信息
Int J Mol Sci. 2020 Feb 20;21(4):1430. doi: 10.3390/ijms21041430.
Abstract
Fetal growth is regulated by a complex interaction of maternal, placental, and fetal factors. The effects and outcomes that chemicals, widely distributed in the environment, may have on the health status of both the mother and the fetus are not yet well defined. Mainly mixtures of chemical substances are found in the mothers and placenta. Exposure to endocrine-disrupting chemicals (EDCs) can be associated with fetal growth retardation, thyroid dysfunction, and neurological disorders. EDCs mostly interfere with insulin, glucocorticoid, estrogenic, and thyroid pathways, with subsequent effects on normal endocrine and metabolic functions, which cause changes in the epigenome and state of inflammation with life-long effects and consequences. International scientific societies recommend the implementation of research and of all possible preventive measures. This review briefly summarizes all these aspects.
摘要
胎儿的生长受母体、胎盘和胎儿因素的复杂相互作用的调节。环境中广泛存在的化学物质可能对母亲和胎儿的健康状况产生的影响和后果尚不清楚。主要是化学物质的混合物存在于母亲和胎盘。接触内分泌干扰化学物质（EDCs）可能与胎儿生长迟缓、甲状腺功能障碍和神经紊乱有关。EDCs 主要干扰胰岛素、糖皮质激素、雌激素和甲状腺途径，随后对正常的内分泌和代谢功能产生影响，导致表观基因组和炎症状态发生变化，产生终身的影响和后果。国际科学学会建议开展研究并采取一切可能的预防措施。这篇综述简要总结了所有这些方面。
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