School of Chemical Engineering, Yeungnam University, Gyeongsan, Republic of Korea.
Advanced Bio Convergence Center, Pohang Technopark Foundation, Pohang, Republic of Korea.
Biofouling. 2020 Feb;36(2):126-137. doi: 10.1080/08927014.2020.1730333. Epub 2020 Feb 24.
Microbial biofilms are associated with persistent infections because of their high tolerance to antimicrobial agents and host defenses. The effects of centipede oil from and its main components were investigated to identify non-toxic biofilm inhibitors. Centipede oil and linoleic acid at 20 µg ml markedly inhibited biofilm formation by two fluconazole-resistant strains and three strains without affecting their planktonic cell growth. Also, both centipede oil and linoleic acid inhibited hyphal growth and cell aggregation by . In addition, centipede oil and linoleic acid showed anti-biofilm activities against mixed and biofilms. Transcriptomic analysis showed that centipede oil and linoleic acid downregulated the expressions of several hypha/biofilm-related genes in and α-hemolysin in . Furthermore, both compounds effectively reduced virulence in a nematode infection model with minimal toxicity.
微生物生物膜因其对抗菌药物和宿主防御的高耐受性而与持续性感染有关。本研究旨在调查蜈蚣油及其主要成分对非毒性生物膜抑制剂的作用。结果表明，蜈蚣油和亚油酸在 20μg/ml 时显著抑制了两种氟康唑耐药 株和三种 株的生物膜形成，而不影响其浮游细胞生长。此外，蜈蚣油和亚油酸均抑制了 的菌丝生长和细胞聚集。此外，蜈蚣油和亚油酸对混合 和 生物膜均具有抗生物膜活性。转录组分析表明，蜈蚣油和亚油酸下调了 和 中几种菌丝/生物膜相关基因的表达以及 的α-溶血素。此外，这两种化合物在最小毒性的线虫感染模型中均能有效降低 的毒力。
