School of Psychology, Research Center in Psychology (Cipsi), University of Minho , Braga, Portugal.
School of Psychology, University of Minho , Braga, Portugal.
Psychol Health Med. 2020 Dec;25(10):1247-1257. doi: 10.1080/13548506.2020.1728350. Epub 2020 Feb 24.
Patients with systemic lupus erythematosus (SLE) experience chronic symptoms that negatively impact their quality of life (QoL). This study analyzed the variables that contributed to QoL in patients with SLE, including the mediating role of psychological morbidity and disease activity. This study used a transversal design and included 104 women with SLE. Participants answered several instruments assessing fatigue, psychological morbidity (depression and anxiety), body image, disease activity, and quality of life. The results showed that disease activity, fatigue severity, psychological morbidity and body image were associated with all domains of QoL. Additionally, psychological morbidity and disease activity mediated the relationship between body image and psychological morbidity. Also, disease activity mediated the relationship between body image and fatigue severity. According to the results, intervention in patients with SLE should focus on patients' psychological morbidity, particularly in the active phase of the disease. Body image, fatigue severity and psychological morbidity should be monitored in patients with SLE in order to promote QoL.
系统性红斑狼疮（SLE）患者会经历慢性症状，这些症状会对其生活质量（QoL）产生负面影响。本研究分析了导致 SLE 患者 QoL 下降的变量，包括心理病态和疾病活动度的中介作用。本研究采用横断面设计，纳入了 104 名女性 SLE 患者。参与者回答了几个评估疲劳、心理病态（抑郁和焦虑）、身体形象、疾病活动度和生活质量的工具。结果表明，疾病活动度、疲劳严重程度、心理病态和身体形象与 QoL 的所有领域均相关。此外，心理病态和疾病活动度在身体形象和心理病态之间起中介作用。同样，疾病活动度在身体形象和疲劳严重程度之间起中介作用。根据这些结果，SLE 患者的干预措施应侧重于患者的心理病态，尤其是在疾病活动期。应监测 SLE 患者的身体形象、疲劳严重程度和心理病态，以提高其生活质量。
