Schjøtt Jan, Erdal Hilde, Opskar Sofie, Bjånes Tormod K
Regional Medicines Information and Pharmacovigilance Centre (RELIS Vest), Haukeland University Hospital, Bergen, Norway.
Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.
BMC Res Notes. 2020 Feb 24;13(1):100. doi: 10.1186/s13104-020-04949-y.
Nonsteroidal anti-inflammatory drugs (NSAIDS) are associated with concern of adverse drug reactions (ADRS) including gastrointestinal, cardiovascular, renal, and musculoskeletal. Non-selective and selective NSAIDS are proposed to differ with regard to their potential to cause ADRS. The aim of this pilot study was to compare perception of prescribing factors and purchase statistics of NSAIDS among physicians in a Norwegian orthopedic clinic.
Forty-five (55%) of 82 invited physicians from the orthopedic clinic participated anonymous in a survey in February 2017. Effect and ADRS were rated as the most important factors for prescribing of NSAIDS. The participants were equally concerned about specific ADRS for prescription of non-selective and selective NSAIDS irrespective of type of ADR. They were generally more concerned about cardiovascular, gastrointestinal and renal ADRS than musculoskeletal. Purchase statistics from 2015 and 2016 showed that celecoxib, a selective NSAID, dominated in the orthopedic clinic. The discrepancy between perception of prescribing factors and purchase statistics of NSAIDS was possibly explained by a high degree of conformity to clinic guidelines. Our preliminary results indicate that perception of prescribing factors of NSAIDS among orthopedics should be surveyed in multicenter or multinational studies.
非甾体抗炎药（NSAIDs）与包括胃肠道、心血管、肾脏和肌肉骨骼等方面的药物不良反应（ADRs）相关。非选择性和选择性NSAIDs在引发ADRs的可能性方面被认为存在差异。这项初步研究的目的是比较挪威一家骨科诊所医生对NSAIDs处方因素的认知以及NSAIDs的购买统计数据。
2017年2月，来自该骨科诊所的82名受邀医生中有45名（55%）匿名参与了一项调查。疗效和ADRs被评为NSAIDs处方的最重要因素。无论ADR的类型如何，参与者对非选择性和选择性NSAIDs处方的特定ADRs同样关注。他们通常对心血管、胃肠道和肾脏ADRs比肌肉骨骼ADRs更为关注。2015年和2016年的购买统计数据显示，选择性NSAID塞来昔布在该骨科诊所占主导地位。NSAIDs处方因素认知与购买统计数据之间的差异可能是由于高度遵循临床指南所致。我们的初步结果表明，应在多中心或跨国研究中调查骨科医生对NSAIDs处方因素的认知。
