Li Xi, Su Jindi, Chen Shiguo, Lin Sheng, Zheng Xiujie, Wang Baojiang, Yao Keqin, Lai Liping, Duan Shan
Laboratory of Medical Genetics, Shenzhen Health Development Research Center, 4009 Xinzhou Road, Futian District, Shenzhen, 518040, China.
Endocrine Department, Futian Center for Chronic Disease Control, 9 Xinsha Road, Futian District, Shenzhen, China.
BMC Res Notes. 2020 Feb 24;13(1):102. doi: 10.1186/s13104-020-04953-2.
The arachidonate 5-lipoxygenase (ALOX5) pathway has been investigated in diverse chronic inflammatory diseases including metabolic disorders. Recently, the ALOX5 polymorphism rs4987105 was identified to confer susceptibility to type 2 diabetes mellitus (T2DM), implicating its role in regulating glucose homeostasis. Gestational diabetes mellitus (GDM) shares similar pathogenic mechanism with T2DM. Thus, we aimed to evaluate the association between rs4987105 and gestational glucose metabolism in Chinese pregnant women.
A total of 380 unrelated Chinese pregnant women including 241 GDM patients and 139 controls were included in this study. The genotypes of rs4987105 were examined by the Agena MassARRAY iPLEX platform, the association between rs4987105 and fasting plasma glucose (FPG) levels at 24-28 gestational weeks was evaluated using different statistical methods. We found that carriers of rs4987105 CT/TT genotypes exhibited significantly lower FPG levels (P = 0.011). In addition, we observed a significant association between rs4987105 and FPG levels after adjusting confounding variables in the linear regression analysis using dominant genetic model (b = - 0.218; P = 0.01). The present study for the first time reported that the rs4987105 of 5-lipoxygenase (ALOX5) gene was associated with gestational glucose metabolism in Chinese pregnant women.
已在包括代谢紊乱在内的多种慢性炎症性疾病中对花生四烯酸5-脂氧合酶（ALOX5）途径进行了研究。最近，已确定ALOX5基因多态性rs4987105赋予2型糖尿病（T2DM）易感性，这暗示了其在调节葡萄糖稳态中的作用。妊娠期糖尿病（GDM）与T2DM具有相似的致病机制。因此，我们旨在评估rs4987105与中国孕妇妊娠期间葡萄糖代谢之间的关联。
本研究共纳入380名无亲缘关系的中国孕妇，其中包括241名GDM患者和139名对照。通过Agena MassARRAY iPLEX平台检测rs4987105的基因型，使用不同的统计方法评估rs4987105与妊娠24 - 28周时空腹血糖（FPG）水平之间的关联。我们发现rs4987105 CT/TT基因型携带者的FPG水平显著较低（P = 0.011）。此外，在使用显性遗传模型的线性回归分析中，调整混杂变量后，我们观察到rs4987105与FPG水平之间存在显著关联（b = - 0.218；P = 0.01）。本研究首次报道5-脂氧合酶（ALOX5）基因的rs4987105与中国孕妇的妊娠葡萄糖代谢有关。
