Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Singapore Institute for Clinical Sciences, Agency for Science and Technology Research (A*STAR), Singapore, Singapore.
BMC Pregnancy Childbirth. 2017 Oct 18;17(1):364. doi: 10.1186/s12884-017-1537-8.
Few studies have investigated physical activity (PA) and sedentary behavior (SB) in relation to fasting (FG) and 2-h postprandial plasma glucose (2hPG) levels and gestational diabetes mellitus (GDM); we investigated these associations among Asian pregnant women.
As part of the Growing Up in Singapore Towards healthy Outcomes cohort study, PA and SB (sitting and television times) were assessed by interviewer-administered questionnaire. During 75 g oral glucose tolerance tests at 26-28 weeks' gestation we measured FG, 2hPG levels and GDM (FG ≥ 7.0 mmol/L and/or 2hPG ≥ 7.8 mmol/L). Associations were analysed by multiple linear and logistic regression.
Among the 1083 women studied, 18.6% had GDM. SB was not associated with FG, 2hPG and GDM. Higher categories of PA were associated with lower 2hPG and a lower likelihood of GDM (p-trend < 0.05), but not with FG levels. Compared to insufficiently active women, highly active women had lower 2hPG levels [β (95% CI): -0.32 (-0.59, -0.05), p = 0.020) and were less likely to have GDM [OR: 0.56 (0.32-0.98), p = 0.040]. Stratified analysis revealed no associations among under/normal-weight women, but significant associations among overweight/obese women; in those with BMI ≥23 kg/m, sufficiently active and highly active women were less likely to have GDM [OR: 0.52, (0.29-0.93), p = 0.028, and OR: 0.34, (0.15-0.77), p = 0.010, respectively].
Higher PA was associated with lower 2hPG levels and a lower prevalence of GDM, particularly in overweight/obese women. Further studies are warranted to confirm these findings, and to examine the effectiveness of PA promotion strategies for the prevention of gestational hyperglycemia.
很少有研究调查体力活动（PA）和久坐行为（SB）与空腹（FG）和餐后 2 小时血糖（2hPG）水平以及妊娠糖尿病（GDM）之间的关系；我们调查了亚洲孕妇的这些关联。
作为新加坡成长为健康结局队列研究的一部分，通过访谈者管理的问卷评估 PA 和 SB（坐和看电视时间）。在 26-28 周妊娠时进行 75g 口服葡萄糖耐量试验期间，我们测量了 FG、2hPG 水平和 GDM（FG≥7.0mmol/L 和/或 2hPG≥7.8mmol/L）。通过多元线性和逻辑回归分析关联。
在研究的 1083 名女性中，18.6%患有 GDM。SB 与 FG、2hPG 和 GDM 无关。更高类别的 PA 与更低的 2hPG 和更低的 GDM 发生可能性相关（p 趋势<0.05），但与 FG 水平无关。与体力活动不足的女性相比，高度活跃的女性 2hPG 水平较低 [β（95%CI）：-0.32（-0.59，-0.05），p=0.020]，并且发生 GDM 的可能性较低 [OR：0.56（0.32-0.98），p=0.040]。分层分析显示在低/正常体重女性中没有关联，但在超重/肥胖女性中存在显著关联；在 BMI≥23kg/m 的女性中，足够活跃和高度活跃的女性发生 GDM 的可能性较低 [OR：0.52（0.29-0.93），p=0.028，和 OR：0.34（0.15-0.77），p=0.010]。
更高的 PA 与更低的 2hPG 水平和更低的 GDM 患病率相关，尤其是在超重/肥胖女性中。需要进一步的研究来证实这些发现，并研究促进 PA 策略对预防妊娠高血糖的有效性。
