甜杏仁（）悬浮液对实验性高脂血症小鼠血液生化参数的影响。需注意，原文中“sweet almond ()”括号内内容缺失，可能会影响对完整意思的准确理解。

Effects of sweet almond () suspension on blood biochemical parameters in experimentally induced hyperlipidemic mice.

作者信息

Tarmoos Afaf A, Kafi Lubna A

机构信息

Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq.

Department of Pharmacology, College of Medicine, Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.

出版信息

Vet World. 2019 Dec;12(12):1966-1969. doi: 10.14202/vetworld.2019.1966-1969. Epub 2019 Dec 14.

DOI:10.14202/vetworld.2019.1966-1969

PMID:32095048

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6989330/

Abstract

AIM

The present study aimed to examine the effects of sweet almond () suspension (SAS) on the measurements of blood biochemical parameters in male albino mice, in which hyperlipidemia was induced experimentally.

MATERIALS AND METHODS

Seventy male albino mice were divided randomly into seven groups (10 mice/group). The first group was the untreated control group (negative control). The second group comprised hyperlipidemic mice that did not receive SAS treatment (positive control). The other five groups consisted of hyperlipidemic mice that were orally administered five different doses of SAS (285, 571, 857, 1128, and 1428 mg/kg body weight). Hyperlipidemia was induced in mice by adding 1% cholesterol to the diet along with 0.5% HO to the drinking water, with access to both food and water for 60 consecutive days. Prothrombin time, partial thromboplastin time, clotting time, and platelet count were measured. Serum lipid profile (total cholesterol [TC], triacylglycerol [TAG], low-density lipoprotein cholesterol [LDL-C], very LDL-C [VLDL-C], and high-density lipoprotein cholesterol [HDL-C]) was also determined.

RESULTS

Prothrombin time, partial thromboplastin time, and clotting time significantly increased only in groups treated with SAS, especially at the dosage of 1428 mg/kg compared with the positive control group. Blood platelet count significantly decreased in SAS-treated groups. The serum levels of TC, TAG, LDL-C, and VLDL-C in the SAS-treated groups (857, 1128, and 1428 mg/kg) significantly decreased, whereas the serum level of HDL-C significantly increased compared with that of the positive control group.

CONCLUSION

SAS administered orally at 1428 mg/kg body weight was the dose that most significantly decreased platelet count and serum levels of TC, TAG, LDL-C, and VLDL-C and increased prothrombin time, partial thromboplastin time, and clotting time as well as serum level of HDL-C in experimentally induced hyperlipidemic mice.

摘要

目的

本研究旨在检测甜杏仁（）悬浮液（SAS）对实验性诱导高脂血症的雄性白化小鼠血液生化参数测定值的影响。

材料与方法

70只雄性白化小鼠随机分为7组（每组10只）。第一组为未处理的对照组（阴性对照）。第二组为未接受SAS治疗的高脂血症小鼠（阳性对照）。其他五组为由口服五种不同剂量SAS（285、571、857、1128和1428毫克/千克体重）的高脂血症小鼠组成。通过在饮食中添加1%胆固醇以及在饮用水中添加0.5%HO诱导小鼠高脂血症，连续60天自由获取食物和水。测量凝血酶原时间、部分凝血活酶时间、凝血时间和血小板计数。还测定了血清脂质谱（总胆固醇[TC]、三酰甘油[TAG]、低密度脂蛋白胆固醇[LDL-C]、极低密度脂蛋白胆固醇[VLDL-C]和高密度脂蛋白胆固醇[HDL-C]）。

结果

仅在接受SAS治疗的组中，凝血酶原时间、部分凝血活酶时间和凝血时间显著增加，尤其是与阳性对照组相比，在1428毫克/千克剂量时。接受SAS治疗的组中血小板计数显著降低。与阳性对照组相比，接受SAS治疗的组（857、1128和1428毫克/千克）中TC、TAG、LDL-C和VLDL-C的血清水平显著降低，而HDL-C的血清水平显著升高。