Isenberg H D
Division of Microbiology, Long Island Jewish Medical Center, New Hyde Park, New York 11042.
J Antimicrob Chemother. 1988 Jul;22 Suppl A:73-86. doi: 10.1093/jac/22.supplement_a.73.
Antibiotic susceptibility test results must be interpreted cautiously. There are important differences between the laboratory and natural environments. There are also important differences between disc and dilution tests, and between laboratories. Laboratory tests can demonstrate antagonism and synergy. Because beta-lactamases can be induced, beta-lactam susceptibility may have to be monitored during therapy. Increases in the incidence of drug resistance are particularly important in nosocomial infections.
抗生素敏感性测试结果必须谨慎解读。实验室环境与自然环境之间存在重要差异。纸片法和稀释法测试之间、不同实验室之间也存在重要差异。实验室测试可以显示拮抗作用和协同作用。由于β-内酰胺酶可被诱导，因此在治疗期间可能必须监测β-内酰胺类药物的敏感性。耐药性发生率的增加在医院感染中尤为重要。
