抑制硫酸吲哚酚诱导的肾内肾素-血管紧张素系统激活：靶向芳烃受体
Inhibition of indoxyl sulfate-induced intrarenal renin-angiotensin system activation: targeting the aryl hydrocarbon receptor.
作者信息
Akbar Muhammad Firman
机构信息
Department of General Health Service, Sahabat Sehat Clinic, West Nusa Tenggara, Indonesia, Department of Medicine, University of Melbourne St. Vincent's Hospital Melbourne, Australia.
出版信息
Transl Clin Pharmacol. 2017 Sep;25(3):114-116. doi: 10.12793/tcp.2017.25.3.114. Epub 2017 Sep 15.
Abstract
Indoxyl sulfate, a protein-bound uremic toxin, leads to CKD (chronic kidney disease) progression and its complications through the activation of AhR (aryl hydrocarbon receptor) and RAS (renin-angiotensin system). Inhibition of these pathways may slow the development of CKD and CKD-associated complications.
摘要
硫酸吲哚酚是一种与蛋白质结合的尿毒症毒素，通过激活芳烃受体（AhR）和肾素-血管紧张素系统（RAS）导致慢性肾脏病（CKD）进展及其并发症。抑制这些途径可能会减缓CKD及其相关并发症的发展。
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